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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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RBL2 / RB2 p130 Antibody (C‑Terminus) LS‑C17614
RB2 p130 antibody LS-C17614 is an unconjugated rabbit polyclonal antibody to RB2 p130 (RBL2) from human, mouse and rat. Validated for ELISA, IHC, IP and WB.
Antibody
Catalog
Size
Price
LS-C17614-100
100 µl
$680

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Product Description

RB2 p130 antibody LS-C17614 is an unconjugated rabbit polyclonal antibody to RB2 p130 (RBL2) from human, mouse and rat. Validated for ELISA, IHC, IP and WB.
About RBL2 / RB2 p130
Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Q08999 NM_005611 NP_005602.3

RBL2 Antibody, p130 Antibody, Retinoblastoma-like 2 (p130) Antibody, RBR-2 Antibody, Rb2 Antibody, Retinoblastoma-like protein 2 Antibody


Specifications

Target
Human RBL2 / RB2 p130
Host
Rabbit
Reactivity
Human, Mouse, Rat (tested or 100% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Unconjugated
Purification
Antiserum
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin
  • Western blot (1:500 - 1:2000)
  • Immunoprecipitation
  • ELISA (1:5000 - 1:20000)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
RBL2 / RB2 p130 antibody was raised against rb2 (p130) peptide corresponding to the C-terminus of the human protein conjugated to KLH.
Epitope
C-Terminus
Specificity
Reacts with a 130kD Rb2 protein from human, rat and mouse tissue. No reaction was observed against other related tumor suppressor proteins. Cross-reactivity with Rb2 (p130) from other species may also occur.
Usage
Suitable for use in ELISA, Western Blot, Immunoprecipitation, and Immunohistochemistry. ELISA: 1:5000-1:20000. Western Blot: 1:500-1:2000. Immunohistochemistry (Paraffin embedded): 1:200-1:1000.
Presentation
PBS, pH 7.2, 0.01% Sodium Azide
Storage
Short term: 4°C; Long term: Add glycerol (40-50%) -20°C.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Requested From: United States
Date Requested: 8/18/2018

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