Human RB1 / Retinoblastoma / RB

Mouse

Human, Mouse (tested or 100% immunogen sequence identity)

IgG1 Monoclonal

172C1094

Unconjugated

Protein G purified

Unmodified

A synthetic peptide corresponding to a region of the caspase-3-induced cleavage site of human Rb.

recognizes cleaved Rb (DRb-p70). Does not recognize full-length Rb. In camptothecin treated HL60, an ~68 kD band is observed. DRb-p70 exists in vivo as an N-terminally truncated form of Rb (Liu et al.). DRb-p70 is thought to be the product of alternative translation and is expressed in primary myeloid cells in fetal liver, bone marrow and spleen. DRb-p70 is also specifically expressed in tumor-associated macrophages (TAMs). TAMs are an important targets of cancer therapy. DRb-p70 is a marker of TAMs, and maybe useful for identifying tumors with macrophage infiltration (Liu et al, 2005).

• IHC
• Western blot (2 µg/ml)

• IHC - Paraffin

PBS, 0.02% Sodium Azide

Short term: 4°C; Long term: -70°C.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: P06400 NCBI: NM_000321 NP_000312.2