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RALDH2 / ALDH1A2 belongs to the aldehyde dehydrogenase family of proteins. The product of this gene is an enzyme that catalyzes the synthesis of retinoic acid (RA) from retinaldehyde. Retinoic acid, the active derivative of vitamin A (retinol), is a hormonal signaling molecule that functions in developing and adult tissues. The studies of a similar mouse gene suggest that this enzyme and the cytochrome CYP26A1, concurrently establish local embryonic retinoic acid levels which facilitate posterior organ development and prevent spina bifida. Four transcript variants encoding distinct isoforms have been identified for this gene.
Gene Name: | aldehyde dehydrogenase 1 family, member A2 |
Synonyms: | ALDH1A2, RALDH2-T, RALDH(II), RALDH 2, RALDH2, Retinal dehydrogenase 2 |
Target Sequences: | NM_003888 NP_003879.2 O94788 |
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