Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone 4H9] (IgG1) to Human RAD50
Western blot, Immunoprecipitation
Human (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [4H9]
Protein G purified
Specificity and Use
RAD50 antibody was raised against gST fusion protein corresponding to the complete coding region (aa 1-425) of Rad50 expressed in E. coli.
human Rad50, a 153 kD protein involved in DNA double strand break repair. Rad50 is associated with Mre11 and p95 (Nibrin) to form a multiprotein complex. Following DNA damage, Rad50 and Mre11 redistribute and are co-localized within the nucleus of damaged cells
RAD50 Antibody, DNA repair protein RAD50 Antibody, HRad50 Antibody, NBSLD Antibody, RAD50 (S. cerevisiae) homolog Antibody, RAD50 homolog (S. cerevisiae) Antibody, RAD502 Antibody, RAD50-2 Antibody
Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity.