Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Human, Monkey (tested or 100% immunogen sequence identity)
Horse (at least 90% immunogen sequence identity)
Western blot (1:500 - 1:1000)
Specificity and Use
RAD17 antibody was raised against synthetic peptide from human RAD17. Percent identity by BLAST analysis: Human, Gibbon, Monkey (100%); Panda, Horse (93%); Gorilla, Orangutan, Hamster, Dog, Bat, Pig (86%).
Residues 2-15 [NQVTDWVDPSFDDF] of the human RAD17 protein
RAD17 is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage.