RAC1

ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)

Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Stimulates PKN2 kinase activity. In concert with RAB7A, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. In glioma cells, promotes cell migration and invasion. In podocytes, promotes nuclear shuttling of NR3C2; this modulation is required for a proper kidney functioning. Required for atypical chemokine receptor ACKR2-induced LIMK1-PAK1-dependent phosphorylation of cofilin (CFL1) and for up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3.Isoform B has an accelerated GEF-independent GDP/GTP exchange and an impaired GTP hydrolysis, which is restored partially by GTPase-activating proteins. It is able to bind to the GTPase-binding domain of PAK but not full-length PAK in a GTP-dependent manner, suggesting that the insertion does not completely abolish effector interaction.

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Products

Antibodies (66)

Proteins (13)

ELISA Kits (11)

Type

Custom (4)

Over-Expression Lysate (5)

Primary (66)

Recombinant (8)

Sandwich (6)

Sandwich CLIA (1)

Target

RAC1 (90)

Reactivity

Human (69)

Mouse (26)

Rat (25)

Bat (5)

Bovine (7)

Chicken (6)

Chimpanzee (3)

Dog (7)

Drosophila (1)

Gibbon (3)

Guinea pig (4)

Hamster (2)

Horse (5)

Monkey (6)

Pig (4)

Rabbit (6)

Sheep (6)

Xenopus (6)

Zebrafish (6)

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IHC (26)

IHC-P (10)

WB (61)

Flo (1)

ELISA (14)

ICC (1)

IF (6)

IP (2)

Peptide-ELISA (1)

Host

rabbit (62)

mouse (4)

Product Group

IHCPlus (2)

Isotype

IgG (26)

IgG1 (1)

IgG2b (3)

Clonality

monoclonal mc (4)

polyclonal pc (62)

Clone

1301CT276.121.104 (1)

23A8 (1)

Format

12 x 8-Well Microstrips (1)

96-Well Microplate (1)

96-Well Strip Plate (9)

AP Conjugated (1)

APC (1)

APC Conjugated (4)

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Atto 488 Conjugated (1)

Atto 594 Conjugated (1)

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Epitope

aa1-189 (8)

Ser71 (7)

pSer71 (6)

Internal (5)

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aa1-196 (1)

aa130-141 (1)

aa169-189 (1)

Publications

No (89)

Yes (1)

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Cell Lysates (3)

Plasma (4)

Serum (4)

Tissue Homogenates (4)

Tag

6His, N-terminus (1)

GST (2)

His (1)

His-S (1)

Myc-DDK (Flag) (7)

Species

Human (11)

Source

293T Cells (3)

Baculovirus (1)

E. coli (4)

HEK 293 Cells (4)

Wheat Germ Extract (1)

Purification

Purified (1)

Low Endotoxin Level

Low endotoxin level (2)

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IHC-plus™ RAC1 Antibody LS-B6306

(4.0) Rating

Antibody:

RAC1 Mouse anti-Human Monoclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

50 µg/$645

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RAC1 Antibody LS-C482866

Antibody:

RAC1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$286; 100 µl/$321; 200 µl/$386

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Rat RAC1 (Sandwich ELISA) ELISA Kit - LS-F7822

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

78 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$965

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RAC1 Antibody (phospho-Ser71) LS-C9853

(4.1) Rating

(2) Publication(s)

Antibody:

RAC1 Rabbit anti-Human Polyclonal (pSer71) Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$689

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RAC1 Antibody (C-Terminus) LS-B11533

Antibody:

RAC1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

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RAC1 Antibody (C-Terminus, Biotin) LS-C464102

Antibody:

RAC1 Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody

Reactivity:

Xenopus, Chicken, Zebrafish, Pig, Horse, Bat, Rat, Sheep, Bovine, Rabbit, Mouse, Dog, Guinea pig, Human, Monkey, Gibbon, Chimpanzee

Applications:

IHC, IHC-P, WB

Format:

Biotin Conjugated

Price:

100 µl/$469

• Unconjugated
• Biotin

• Unconjugated
• Biotin

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Mouse RAC1 (Sandwich ELISA) ELISA Kit - LS-F66631

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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Human RAC1 (Sandwich ELISA) ELISA Kit - LS-F9124

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$902

Select

RAC1 Antibody (aa169-189) LS-C407644

Antibody:

RAC1 Rabbit anti-Human Polyclonal (aa169-189) Antibody

Reactivity:

Xenopus, Chicken, Zebrafish, Pig, Bat, Sheep, Bovine, Rabbit, Mouse, Dog, Rat, Hamster, Human

Applications:

WB

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

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RAC1 Antibody (clone 1301CT276.121.104) LS-C344161

Antibody:

RAC1 Mouse anti-Human Monoclonal (1301CT276.121.104) Antibody

Reactivity:

Rat, Human

Applications:

Flo, IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

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Rat RAC1 (CLIA) ELISA Kit - LS-F29985

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Rat

Range:

31.25 - 2000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$728

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RAC1 Antibody (Internal) LS-C118233

Antibody:

RAC1 Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

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RAC1 Antibody (aa1-196) LS-C185382

Antibody:

RAC1 Rabbit anti-Human Polyclonal (aa1-196) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$450

Select

RAC1 Antibody (clone 23A8) LS-C85408

Antibody:

RAC1 Mouse anti-Human Monoclonal (23A8) Antibody

Reactivity:

Human

Applications:

IHC, IP, WB

Format:

Unconjugated

Price:

25 µg/$1,387

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RAC1 Antibody (Ser71, Azide-free, HRP) LS-C281865

Antibody:

RAC1 Rabbit anti-Human Polyclonal (Ser71) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

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RAC1 Antibody LS-C679267

Antibody:

RAC1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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RAC1 Antibody (phospho-Ser71) LS-C9854

Antibody:

RAC1 Rabbit anti-Human Polyclonal (pSer71) Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Unconjugated

Price:

10 Blots/$842

Select

RAC1 Antibody (aa1-189) LS-C373799

Antibody:

RAC1 Rabbit anti-Human Polyclonal (aa1-189) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$319; 200 µl/$365; 500 µl/$519; 1 ml/$597; 2 ml/$826; 5 ml/$1,352

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RAC1 Antibody LS-C755197

Antibody:

RAC1 Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µg/$351

Select

RAC1 Antibody LS-C755193

Antibody:

RAC1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µg/$351

Select

RAC1 Antibody LS-C409274

Antibody:

RAC1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

Select

Mouse RAC1 (Sandwich ELISA) ELISA Kit - LS-F55724

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$923

Select

Human RAC1 (Sandwich ELISA) ELISA Kit - LS-F21131

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$651

Select

Human RAC1 Protein (Recombinant His) - LS-G625

Source:

E. coli

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Price:

100 µg/$317; 500 µg/$526; 20 µg/$245

Select

Human RAC1 Protein (Recombinant) - LS-G3537

Source:

E. coli

Tag:

None

Price:

100 µg/$317; 500 µg/$526; 20 µg/$245

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