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RAB8A / RAB8

RAB8A, member RAS oncogene family

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B and RAB11A participates in epithelial cell polarization. Plays an important role in ciliogenesis. Together with MICALL2, may also regulate adherens junction assembly. May play a role in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore play a role in glucose homeostasis.

Gene Name: RAB8A, member RAS oncogene family
Family/Subfamily: Ras GTPase superfamily IPR001806 , not assigned-Ras GTPase superfamily IPR001806
Synonyms: RAB8A, RAB8, Ras-related protein rab-8, Oncogene c-mel, Ras-associated protein RAB8, Ras-related protein Rab-8A, MEL
Target Sequences: NM_005370 NP_005361.2 P61006

Publications (2)

1
Understanding LRRK2 kinase activity in preclinical models and human subjects through quantitative analysis of LRRK2 and pT73 Rab10. Xiang Wang, Elvira Negrou, Michael T Maloney, Vitaliy V Bondar, Shan V Andrews, Manuel Montalban, Ceyda Llapashtica, Romeo Maciuca, Hoang Nguyen, Hilda Solanoy, Annie Arguello, Laralynne Przybyla, Nathan J Moerke, Sarah Huntwork-Rodriguez, Anastasia G Henry. Scientific reports. 2021 June;11:12900. [Full Text Article] [PubMed:34145320] [PMC:PMC8213766]
2
A dileucine motif in the COOH-terminal domain of NKCC1 targets the cotransporter to the plasma membrane. Rainelli Koumangoye, Salma Omer, Eric Delpire. American journal of physiology. Cell physiology. 2019 Apr;316:C545-C558. [Full Text Article] [PubMed:30865516] [PMC:PMC6482672] Related Antibodies: LS-B9782.

☰ Filters
Antibodies (15)
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RAB8A / RAB8 (27)
Human (17)
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rabbit (10)
mouse (2)
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monoclonal mc (2)
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aa170-183 (1)
aa186-198 (1)
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GST, N-terminus (1)
Myc-DDK (Flag) (3)
Human (4)
293T Cells (1)
HEK 293 Cells (2)
Wheat Germ Extract (2)
Purified (1)
RAB8A / RAB8 Antibody - Anti-RAB8A / RAB8 antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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RAB8A / RAB8 Goat anti-Mouse Polyclonal (C-Terminus) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, WB
Unconjugated
300 µg/$460
RAB8A / RAB8 Antibody - Anti-RAB8A / RAB8 antibody IHC staining of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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RAB8A / RAB8 Mouse anti-Human Monoclonal (3G1) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
RAB8A / RAB8 Protein - 12.5% SDS-PAGE of human RAB8A stained with Coomassie Blue
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Wheat Germ Extract
GST
48.4 kDa
10 µg/$479; 25 µg/$670
RAB8A / RAB8 Protein - Purified recombinant protein RAB8A was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
23.5 kDa
20 µg/$1,107
Select
293T Cells
Myc-DDK (Flag)
23.5 kDa
20 µg/$150
RAB8A / RAB8 Antibody - RAB8A / RAB8 antibody. IHC(P): Human Intestinal Cancer Tissue.
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RAB8A / RAB8 Rabbit anti-Human Polyclonal (aa170-183) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
RAB8A / RAB8 Antibody - Western blot analysis using Rab8 mAb against human Rab8 (AA: 68-207) recombinant protein. (Expected MW is 42 kDa)
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RAB8A / RAB8 Mouse anti-Human Monoclonal (7G8B11) Antibody
Human
ELISA, Flo, WB
Unconjugated
100 µl/$459
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RAB8A / RAB8 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IP, WB
Unconjugated
100 µg/$331
RAB8A / RAB8 Antibody - Immunohistochemistry of paraffin-embedded Human brain using RAB8A Polyclonal Antibody at dilution of 1:45.
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RAB8A / RAB8 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
RAB8A / RAB8 Antibody - Human Kidney, Glomerulus, Nuclear Staining: Formalin-Fixed, Paraffin-Embedded (FFPE)
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RAB8A / RAB8 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC-P, WB
Unconjugated
100 µl/$424
RAB8A / RAB8 Antibody - RAB8A antibody Western blot of 721_B Cell lysate. Antibody concentration 1 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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RAB8A / RAB8 Rabbit anti-Human Polyclonal (C-Terminus) (HRP) Antibody
Xenopus, Chicken, Zebrafish, Mouse, Dog, Sheep, Bovine, Pig, Horse, Bat, Rat, Gibbon, Orangutan, Human, Monkey, Chimpanzee
WB
HRP Conjugated
100 µl/$469
RAB8A / RAB8 Antibody - RAB8A antibody Western blot of 721_B Cell lysate. Antibody concentration 1 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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RAB8A / RAB8 Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody
Xenopus, Chicken, Zebrafish, Mouse, Dog, Sheep, Bovine, Pig, Horse, Bat, Rat, Gibbon, Orangutan, Human, Monkey, Chimpanzee
WB
Biotin Conjugated
100 µl/$469
RAB8A / RAB8 Antibody - RAB8A antibody Western blot of 721_B Cell lysate. Antibody concentration 1 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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RAB8A / RAB8 Rabbit anti-Human Polyclonal (C-Terminus) (FITC) Antibody
Xenopus, Chicken, Zebrafish, Mouse, Dog, Sheep, Bovine, Pig, Horse, Bat, Rat, Gibbon, Orangutan, Human, Monkey, Chimpanzee
WB
FITC Conjugated
100 µl/$469
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RAB8A / RAB8 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µg/$357
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RAB8A / RAB8 Goat anti-Human Polyclonal (C-Terminus) Antibody
Human
ELISA, WB
Unconjugated
0.1 mg/$558
RAB8A / RAB8 Antibody - Western blot analysis of RAB8A using COS7 whole cells lysates
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RAB8A / RAB8 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human, Monkey
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
RAB8A / RAB8 Antibody - Antibody (0.1 ug/ml) staining of Human Brain (Cerebellum) lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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RAB8A / RAB8 Goat anti-Human Polyclonal (aa186-198) Antibody
Dog, Bovine, Pig, Horse, Human, Monkey
Peptide-ELISA, WB
Unconjugated
100 µg/$503
RAB8A / RAB8 Antibody - Western blot analysis of extracts of HeLa cells.
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RAB8A / RAB8 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
20 µl/$275; 100 µl/$389
RAB8A / RAB8 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
23.5 kDa
100 µg/$494
RAB8A / RAB8 ELISA Kit
Select
Custom
96-Well Strip Plate
Rat
Colorimetric - 450nm (TMB)
1 Plate/$783
RAB8A / RAB8 ELISA Kit
Select
Custom
96-Well Strip Plate
Colorimetric - 450nm (TMB)
1 Plate/$783
RAB8A / RAB8 ELISA Kit
Select
Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$783
RAB8A / RAB8 ELISA Kit
Select
Custom
96-Well Strip Plate
Chicken
Colorimetric - 450nm (TMB)
1 Plate/$929
RAB8A / RAB8 ELISA Kit
Select
Custom
96-Well Strip Plate
Dog
Colorimetric - 450nm (TMB)
1 Plate/$929
RAB8A / RAB8 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
Viewing 1-25 of 27 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).