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RAB11A

RAB11A, member RAS oncogene family

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane. Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes. May also play a role in melanosome transport and release from melanocytes.

Gene Name: RAB11A, member RAS oncogene family
Family/Subfamily: Ras GTPase superfamily IPR001806 , RAS oncogene
Synonyms: RAB11A, Rab-11, RAB11, Ras-related protein Rab-11A, YL8
Target Sequences: NM_004663 NP_004654.1 P62491

Publications (1)

1
Eyes shut homolog (EYS) interacts with matriglycan of O-mannosyl glycans whose deficiency results in EYS mislocalization and degeneration of photoreceptors. Yu Liu , Miao Yu , Xuanze Shang, My Hong Hoai Nguyen, Shanmuganathan Balakrishnan, Rachel Sager, Huaiyu Hu. Scientific reports. 2020 May;10:7795. [Full Text Article] [PubMed:32385361] [PMC:PMC7210881]

☰ Filters
Antibodies (36)
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RAB11A (51)
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monoclonal mc (2)
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1565CT164.36.80 (1)
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RAB11A Antibody - Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE)
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RAB11A Mouse anti-Human Monoclonal (1565CT164.36.80) Antibody
Mouse, Rat, Human
IHC-P, WB
Unconjugated
100 µl/$460
RAB11A Antibody - Immunofluorescent analysis of RAB11A staining in MCF7 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 deg C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark.
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RAB11A Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ICC, IF, WB
Unconjugated
50 µl/$286; 100 µl/$321; 200 µl/$386
RAB11A Antibody - RAB11A antibody staining (2 ug/ml) of mouse heart lysate (RIPA buffer, 30g total protein per lane). Primary incubated for 1 hour. Detected by Western blot of chemiluminescence.
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RAB11A Goat anti-Human Polyclonal (aa204-216) Antibody
Rabbit, Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Bat, Human, Monkey
Peptide-ELISA, WB
Unconjugated
100 µg/$503
RAB11A Antibody - RAB11A antibody Western blot of 721_B Cell lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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RAB11A Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$424
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RAB11A Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IP, WB
Unconjugated
100 µg/$341
RAB11A Antibody - Immunohistochemistry of paraffin-embedded mouse lung cancer using RAB11A antibody at dilution of 1:200 (x400 lens)
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RAB11A Rabbit anti-Human Polyclonal Antibody
Human
IF, IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
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RAB11A Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IP, WB
Unconjugated
100 µg/$331
RAB11A Protein
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E. coli
6His, N-terminus
100 µg/$342; 500 µg/$641; 20 µg/$254
RAB11A Antibody - Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue  using RAB11A Polyclonal Antibody at dilution of 1:35(×200)
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RAB11A Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
RAB11A Antibody - Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue  using RAB11A Polyclonal Antibody at dilution of 1:45(×200)
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RAB11A Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
RAB11A Antibody - Immunohistochemistry of paraffin-embedded human breast cancer using antibody at 1:100 dilution.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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RAB11A Rabbit anti-Human Polyclonal (aa2-213) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
RAB11A Antibody - Immunohistochemistry of paraffin-embedded human breast cancer using antibody at 1:100 dilution.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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RAB11A Rabbit anti-Human Polyclonal (aa2-213) (HRP) Antibody
Human
ELISA, IHC, IHC-P
HRP Conjugated
50 µg/$294; 100 µg/$360
RAB11A Antibody - Immunohistochemistry of paraffin-embedded human breast cancer using antibody at 1:100 dilution.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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RAB11A Rabbit anti-Human Polyclonal (aa2-213) (Biotin) Antibody
Human
ELISA, IHC, IHC-P
Biotin Conjugated
50 µg/$294; 100 µg/$360
RAB11A Antibody - Immunohistochemistry of paraffin-embedded human breast cancer using antibody at 1:100 dilution.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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RAB11A Rabbit anti-Human Polyclonal (aa2-213) (FITC) Antibody
Human
ELISA, IHC, IHC-P
FITC Conjugated
50 µg/$294; 100 µg/$360
RAB11A Antibody - 1:100 staining mouse lung tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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RAB11A Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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RAB11A Rabbit anti-Human Polyclonal Antibody
Human
IF, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
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RAB11A Mouse anti-Human Monoclonal (S1) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$423
RAB11A Antibody - Western blot of RAB11A pAb in extracts from mouse spleen tissue and Jurkat, MCF7, SH-SY5Y cells.
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RAB11A Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
50 µl/$356; 100 µl/$461
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RAB11A Rabbit anti-Human Polyclonal (aa88-116) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
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RAB11A Rabbit anti-Human Polyclonal (aa88-116) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
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RAB11A Rabbit anti-Human Polyclonal (aa88-116) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
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RAB11A Rabbit anti-Human Polyclonal (aa88-116) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
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RAB11A Rabbit anti-Human Polyclonal (aa88-116) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$952
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RAB11A Rabbit anti-Human Polyclonal (aa88-116) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
RAB11A Antibody - Immunofluorescence analysis of C6 cells using RAB11A Polyclonal Antibody at dilution of 1:100.Blue: DAPI for nuclear staining.
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RAB11A Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
Viewing 1-25 of 51 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).