Pyrin / MEFV / MEF

Mediterranean fever

Involved in innate immunity and the inflammatory response. Interacts with several components of the inflammasome complex, a large oligomeric structure which recruits and activates CASP1 and ultimately induces maturation of cytokines such as IL1B. However, the exact role of MEFV in the inflammatory pathway is uncertain as contradictory effects on IL1B processing have been reported in different experimental systems. Has been shown to activate IL1B production (PubMed:16037825). Has also been shown to inhibit IL1B production (PubMed:16785446, PubMed:17431422). Also required for PSTPIP1-induced PYCARD oligomerization and for formation of pyroptosomes, large supramolecular structures composed of oligomerized PYCARD dimers which form prior to inflammatory apoptosis. Can reduce PYCARD-induced apoptosis. Recruits PSTPIP1 to pyroptosomes, and required for PSTPIP1 oligomerization.

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Products

Antibodies (27)

ELISA Kits (5)

Proteins (3)

Type

Custom (2)

Over-Expression Lysate (2)

Primary (27)

Recombinant (1)

Sandwich (3)

Target

Pyrin / MEFV / MEF (35)

Reactivity

Human (30)

Mouse (5)

Rat (3)

Bat (3)

Bovine (3)

Chimpanzee (6)

Dog (3)

Gibbon (3)

Guinea pig (3)

Horse (3)

Monkey (3)

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Application

IHC (1)

IHC-P (1)

WB (23)

ELISA (12)

IP (1)

Peptide-ELISA (2)

Host

rabbit (25)

mouse (1)

goat (1)

Isotype

IgG (18)

IgG2a,k (1)

Clonality

monoclonal mc (1)

polyclonal pc (26)

Clone

4E6 (1)

Format

96-Well Strip Plate (5)

APC Conjugated (1)

Azide-free (1)

Biotin Conjugated (4)

FITC Conjugated (4)

HRP Conjugated (4)

PE Conjugated (1)

Unconjugated (13)

Epitope

N-Terminus (8)

aa418-445 (7)

aa2-29 (1)

aa428-440 (1)

aa5-39 (1)

Publications

No (35)

Sample Type

Plasma (3)

Serum (3)

Tissue Homogenates (1)

Tag

GST, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (2)

Source

293T Cells (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

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Pyrin / MEFV / MEF Antibody (aa2-29) LS-C345063

Antibody:

Pyrin / MEFV / MEF Rabbit anti-Human Polyclonal (aa2-29) Antibody

Reactivity:

Human

Applications:

IP, WB

Format:

Unconjugated

Price:

100 µg/$470

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Pyrin / MEFV / MEF Antibody LS-C680845

Antibody:

Pyrin / MEFV / MEF Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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Pyrin / MEFV / MEF Antibody (HRP) LS-C680851

Antibody:

Pyrin / MEFV / MEF Rabbit anti-Human Polyclonal (HRP) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

HRP Conjugated

Price:

50 µg/$294; 100 µg/$360

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Pyrin / MEFV / MEF Antibody (Biotin) LS-C680848

Antibody:

Pyrin / MEFV / MEF Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Biotin Conjugated

Price:

50 µg/$294; 100 µg/$360

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Pyrin / MEFV / MEF Antibody (FITC) LS-C680847

Antibody:

Pyrin / MEFV / MEF Rabbit anti-Human Polyclonal (FITC) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

FITC Conjugated

Price:

50 µg/$294; 100 µg/$360

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

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Pyrin / MEFV / MEF Antibody (N-Terminus) LS-C31416

Antibody:

Pyrin / MEFV / MEF Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$397

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Pyrin / MEFV / MEF Antibody (N-Terminus, FITC) LS-C427038

Antibody:

Pyrin / MEFV / MEF Rabbit anti-Human Polyclonal (N-Terminus) (FITC) Antibody

Reactivity:

Mouse, Dog, Guinea pig, Bovine, Bat, Gibbon, Human, Monkey, Chimpanzee

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$442

• Unconjugated
• FITC

• Unconjugated
• FITC

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Pyrin / MEFV / MEF Antibody (clone 4E6) LS-C197669

Antibody:

Pyrin / MEFV / MEF Mouse anti-Human Monoclonal (4E6) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$423

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Pyrin / MEFV / MEF Antibody (aa428-440) LS-C55102

Antibody:

Pyrin / MEFV / MEF Goat anti-Human Polyclonal (aa428-440) Antibody

Reactivity:

Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µg/$503

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Human Pyrin / MEFV / MEF (Sandwich ELISA) ELISA Kit - LS-F33871

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Pyrin / MEFV / MEF Antibody LS-C753683

Antibody:

Pyrin / MEFV / MEF Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$351

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Pyrin / MEFV / MEF Antibody (aa418-445) LS-C322950

Antibody:

Pyrin / MEFV / MEF Rabbit anti-Human Polyclonal (aa418-445) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$734

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Pyrin / MEFV / MEF Antibody (aa418-445, Biotin) LS-C262967

Antibody:

Pyrin / MEFV / MEF Rabbit anti-Human Polyclonal (aa418-445) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

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Pyrin / MEFV / MEF Antibody (aa418-445, FITC) LS-C262968

Antibody:

Pyrin / MEFV / MEF Rabbit anti-Human Polyclonal (aa418-445) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

FITC Conjugated

Price:

200 µl/$952

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Pyrin / MEFV / MEF Antibody (aa418-445, APC) LS-C262966

Antibody:

Pyrin / MEFV / MEF Rabbit anti-Human Polyclonal (aa418-445) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

APC Conjugated

Price:

200 µl/$952

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Pyrin / MEFV / MEF Antibody (aa418-445, Azide-free, HRP) LS-C262969

Antibody:

Pyrin / MEFV / MEF Rabbit anti-Human Polyclonal (aa418-445) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

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Pyrin / MEFV / MEF Antibody (aa418-445, PE) LS-C262971

Antibody:

Pyrin / MEFV / MEF Rabbit anti-Human Polyclonal (aa418-445) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

PE Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• HRP, Azide-free
• PE

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • HRP, Azide-free
  • PE

Select

Pyrin / MEFV / MEF Antibody LS-C803911

Antibody:

Pyrin / MEFV / MEF Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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Pyrin / MEFV / MEF Antibody LS-C411133

Antibody:

Pyrin / MEFV / MEF Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

20 µl/$275; 100 µl/$389; 200 µl/$503

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Pyrin / MEFV / MEF Antibody (N-Terminus) LS-C110228

Antibody:

Pyrin / MEFV / MEF Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

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Pyrin / MEFV / MEF Antibody (N-Terminus, HRP) LS-C436260

Antibody:

Pyrin / MEFV / MEF Rabbit anti-Human Polyclonal (N-Terminus) (HRP) Antibody

Reactivity:

Horse, Human, Chimpanzee

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$469

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Pyrin / MEFV / MEF Antibody (N-Terminus, Biotin) LS-C436257

Antibody:

Pyrin / MEFV / MEF Rabbit anti-Human Polyclonal (N-Terminus) (Biotin) Antibody

Reactivity:

Horse, Human, Chimpanzee

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin

• Unconjugated
• HRP
• Biotin

Select

Pyrin / MEFV / MEF Antibody (aa418-445) LS-C157883

Antibody:

Pyrin / MEFV / MEF Rabbit anti-Human Polyclonal (aa418-445) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

400 µl/$393

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Pyrin / MEFV / MEF Antibody LS-C490341

Antibody:

Pyrin / MEFV / MEF Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µg/$575

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Pyrin / MEFV / MEF Antibody (aa5-39) LS-C407879

Antibody:

Pyrin / MEFV / MEF Rabbit anti-Human Polyclonal (aa5-39) Antibody

Reactivity:

Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

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