Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Rat Monoclonal [clone 502-57] (IgG2a) to Mouse PVRL2 / CD112
IHC - Frozen, Western blot, Immunoprecipitation, Flow Cytometry
Mouse PVRL2 / CD112
Mouse, Human (tested or 100% immunogen sequence identity)
IgG2a Monoclonal [502-57]
IHC - Frozen
Western blot (1:10)
Flow Cytometry (1:10)
Specificity and Use
PVRL2 / CD112 antibody was raised against the extracellular domain of mouse nectin-2.
Recognizes mouse Nectin-2. Cross-reacts with human nectin-2.
Can be used for immunoassays, Western Blot, Immunoprecipitation, Flow Cytometry and Immunohistology on frozen sections. Flow Cytometry: 1:10. Western Blot: 1:10. Immunohistology: 1:10; Fixation with PFA or acetone/methanol is recommended.
PBS, 0.1% BSA, 0.002% sodium azide
Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PVRL2 Antibody, HVEB Antibody, Herpesvirus entry protein B Antibody, Poliovirus receptor-like 2 Antibody, Nectin-2 Antibody, PRR2 Antibody, PVRR2 Antibody, CD112 Antibody, CD112 antigen Antibody, Herpes virus entry mediator B Antibody, Herpesvirus entry mediator B Antibody
PVRL2 / CD112 is a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis.