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PVR / CD155

poliovirus receptor

Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. Serves as a receptor for poliovirus attachment to target cells. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport.

Gene Name: poliovirus receptor
Synonyms: PVR, CD155, Hpvr, HVED, Nectin-like 5, Nectin-like protein 5, Poliovirus receptors beta, Poliovirus receptor, PVS, Necl-5, CD155 antigen, NECL5, TAGE4
Target Sequences: NM_006505 NP_006496.4 P15151

Publications (4)

1
Melanoma Cells Control Antimelanoma CTL Responses via Interaction between TIGIT and CD155 in the Effector Phase. Inozume T, Yaguchi T, Furuta J, Harada K, Kawakami Y, Shimada S. The Journal of investigative dermatology. 2016 January;136:255-63. [Full Text Article] [PubMed:26763445]
2
Melanoma Cells Control Anti-Melanoma CTL Responses via Interaction between TIGIT and CD155 in the Effector Phase. Inozume T, Yaguchi T, Furuta J, Harada K, Kawakami Y, Shimada S. The Journal of investigative dermatology. 2016 January;136:255-263. [Full Text Article] [PubMed:26458009]
3
Intratumoral Delivery of a PD-1-Blocking scFv Encoded in Oncolytic HSV-1 Promotes Antitumor Immunity and Synergizes with TIGIT Blockade. Chaolong Lin , Wenfeng Ren , Yong Luo, Shaopeng Li, Yating Chang, Lu Li, Dan Xiong, Xiaoxuan Huang, Zilong Xu, Zeng Yu, Yingbin Wang, Jun Zhang, Chenghao Huang, Ningshao Xia. Cancer immunology research. 2020 May;8:632-647. [Full Text Article] [PubMed:32127389] Related Antibodies: LS-B10536.
4
The CD155/TIGIT axis promotes and maintains immune evasion in neoantigen-expressing pancreatic cancer. William A Freed-Pastor, Laurens J Lambert, Zackery A Ely, Nimisha B Pattada, Arjun Bhutkar, George Eng, Kim L Mercer, Ana P Garcia, Lin Lin, William M Rideout rd, William L Hwang, Jason M Schenkel, Alex M Jaeger, Roderick T Bronson, Peter M K Westcott, Tyler D Hether, Prajan Divakar, Jason W Reeves, Vikram Deshpande, Toni Delorey, Devan Phillips, Omer H Yilmaz, Aviv Regev, Tyler Jacks. Cancer cell. 2021 October;39:1342-1360.e14. [Full Text Article] [PubMed:34358448] [PMC:PMC8511341] Related Antibodies: LS-B12331, LS-C376428.
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Antibodies (80)
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PVR / CD155 (108)
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PVR / CD155 Antibody - Human Pancreas: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Cancer
PVR / CD155 Rabbit anti-Human Polyclonal (aa314-342) Antibody
Human
IHC-P, Peptide-ELISA, WB
Unconjugated
200 µl/$460
PVR / CD155 Antibody - Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE)
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PVR / CD155 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
PVR / CD155 Antibody - Immunohistochemistry of paraffin-embedded human placenta using antibody at 1:100 dilution.
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PVR / CD155 Rabbit anti-Human Polyclonal (aa220-345) Antibody
Mouse, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$294; 100 µl/$360
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PVR / CD155 Mouse anti-Human Monoclonal (aa35-50) Antibody
Human, Monkey
Flo, IF
Unconjugated
500 µl/$876
PVR / CD155 Antibody - Flow cytometry of PVR / CD155 antibody
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PVR / CD155 Mouse anti-Human Monoclonal (ANC2B2) Antibody
Human
ELISA, Flo
Unconjugated
100 µg/$446
PVR / CD155 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$798
Select
PVR / CD155 Rabbit anti-Mouse Monoclonal (305) Antibody
Mouse
Flo, ICC, IF
Unconjugated
20 µl/$271; 100 µl/$412
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
36.13kD
10 µg/$288; 50 µg/$442; 500 µg/$1,585; 1 mg/$2,157
PVR / CD155 Antibody - Flow cytometry of PVR / CD155 antibody
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PVR / CD155 Mouse anti-Human Monoclonal (ANC6A3) Antibody
Human
ELISA, Flo
Unconjugated
100 µg/$446
PVR / CD155 Antibody - PVR / CD155 antibody Western blot of HepG2 Cell lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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PVR / CD155 Rabbit anti-Human Polyclonal (aa78-127) Antibody
Human
WB
Unconjugated
100 µl/$424
PVR / CD155 Antibody
Select
PVR / CD155 Mouse anti-Human Monoclonal (Preservative Free) (ANC2B2) Antibody
Human
ELISA, Flo
Unconjugated, Preservative Free
100 µg/$446
Select
PVR / CD155 Rabbit anti-Human Polyclonal Antibody
Human
IHC, WB
Unconjugated
50 µl/$356; 100 µl/$461
Select
PVR / CD155 Rabbit anti-Human Polyclonal (aa314-342) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
Select
PVR / CD155 Mouse anti-Human Monoclonal (APC) (12K48) Antibody
Human
Flo
APC Conjugated
100 Tests/$832
Select
HEK 293 Cells
Fc, C-terminus
Less than 0.2 EU/µg protein (determined by LAL method).
85-105 kDa
100 µg/$423; 1 mg/$1,475
Select
PVR / CD155 Mouse anti-Human Monoclonal (PerCP) (11n42) Antibody
Human
Flo
PerCP Conjugated
100 Tests/$872
PVR / CD155 Antibody - Western blot of recombinant PVR / CD155.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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PVR / CD155 Rabbit anti-Human Polyclonal (aa56-309) (FITC) Antibody
Mouse, Human
WB
FITC Conjugated
100 µl/$341; 200 µl/$397; 500 µl/$583; 1 ml/$715; 2 ml/$953; 5 ml/$1,628
PVR / CD155 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
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PVR / CD155 Mouse anti-Human Monoclonal (FITC) (9B8G1H5) Antibody
Human
Flo, ICC, IF
FITC Conjugated
25 Tests/$263; 100 Tests/$376
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PVR / CD155 Rabbit Recombinant Monoclonal Antibody
ICC, IHC, IHC-IF, WB
Unconjugated
10 µl/$299; 100 µl/$548
PVR / CD155 Antibody - Immunohistochemistry of paraffin-embedded human placenta using antibody at 1:100 dilution.
Select
PVR / CD155 Rabbit anti-Human Polyclonal (aa220-345) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µl/$294; 100 µl/$360
PVR / CD155 Antibody
Select
PVR / CD155 Mouse anti-Human Monoclonal (Preservative Free) (ANC6A3) Antibody
Human
ELISA, Flo
Unconjugated, Preservative Free
100 µg/$446
Select
PVR / CD155 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IP, WB
Unconjugated
100 µl/$412
Select
PVR / CD155 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IP, WB
Unconjugated
100 µl/$412
Select
PVR / CD155 Mouse anti-Human Monoclonal Antibody
Human
ELISA, WB
Unconjugated
20 µl/$271; 100 µl/$412
Viewing 1-25 of 108 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).