PTPN6 / SHP1

protein tyrosine phosphatase, non-receptor type 6

PTPN6 / SHP1 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported.

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Products

Antibodies (59)

Proteins (15)

ELISA Kits (6)

Type

Cell-Based (1)

Cell-Based Phosphorylation (2)

Custom (1)

Over-Expression Cell Culture Supernatant (1)

Over-Expression Lysate (5)

Primary (59)

Recombinant (9)

Sandwich (2)

Target

PTPN6 / SHP1 (80)

Reactivity

Human (63)

Mouse (25)

Rat (17)

Bovine (1)

Chicken (1)

Chimpanzee (3)

Dog (1)

Gibbon (3)

Hamster (1)

Horse (1)

Monkey (5)

Pig (1)

Rabbit (1)

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Application

IHC (21)

IHC-P (8)

WB (55)

Flo (1)

ELISA (21)

ICC (6)

IF (10)

IP (2)

Peptide-ELISA (9)

Host

rabbit (49)

mouse (8)

goat (2)

Product Group

IHCPlus (2)

Isotype

IgG (30)

IgG1 (1)

IgG1,k (3)

IgG2a (1)

IgG2a,k (1)

Clonality

monoclonal mc (8)

polyclonal pc (51)

Clone

2E9E4 (1)

Format

96-Well Microplate (5)

96-Well Strip Plate (1)

APC (1)

APC Conjugated (1)

Biotin Conjugated (3)

Cy3 Conjugated (1)

Cy7 Conjugated (1)

FITC Conjugated (3)

HRP Conjugated (3)

PE Conjugated (1)

Unconjugated (46)

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Epitope

aa244-515 (8)

pTyr536 (6)

aa245-294 (4)

pTyr564 (4)

480-560 aa (2)

500-580 aa (2)

C-Terminus (2)

Lys530 (1)

aa502-551 (1)

aa530-579 (1)

aa545-595 (1)

aa553-564 (1)

aa570-582 (1)

p536 (1)

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Publications

No (79)

Yes (1)

Sample Type

Adherent Cell Cultures (3)

Plasma (1)

Serum (1)

Tissue Homogenates (1)

Tag

6His, C-terminus (2)

6His, N-terminus (2)

GST (1)

His (1)

His/GST,N-terminus (1)

His-SUMO (1)

Myc-DDK (Flag) (6)

Species

Human (12)

Mouse (1)

Source

293T Cells (2)

E. coli (5)

HEK 293 Cells (6)

Insect Cells (1)

Wheat Germ Extract (1)

Purification

Purified (3)

Low Endotoxin Level

Low endotoxin level (4)

Biologically Active

Biologically active (1)

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PTPN6 / SHP1 Antibody (C-Terminus) LS-C358839

(4.1) Rating

(2) Publication(s)

Antibody:

PTPN6 / SHP1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

30 µl/$255; 100 µl/$299; 200 µl/$351

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PTPN6 / SHP1 Antibody LS-C331469

Antibody:

PTPN6 / SHP1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

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IHC-plus™ PTPN6 / SHP1 Antibody (aa553-564) LS-B7506

(4.0) Rating

Antibody:

PTPN6 / SHP1 Goat anti-Human Polyclonal (aa553-564) Antibody

Reactivity:

Mouse, Rat, Hamster, Human

Applications:

IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µg/$485

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Human PTPN6 / SHP1 Protein (Recombinant) - LS-G3549

Source:

E. coli

Tag:

None

Biological Activity:

Biologically active

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Price:

100 µg/$411; 500 µg/$985; 20 µg/$276

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Human PTPN6 / SHP1 (Sandwich ELISA) ELISA Kit - LS-F8994

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Tissue Homogenates

Price:

1 Plate/$834

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Human Phospho-PTPN6 / SHP1 (Tyr564) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1668

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Human

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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Mouse/Human/Rat Phospho-PTPN6 / SHP1 (Tyr536) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1053

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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PTPN6 / SHP1 Antibody (phospho-Tyr536) LS-C199569

Antibody:

PTPN6 / SHP1 Rabbit anti-Human Polyclonal (pTyr536) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

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Human PTPN6 / SHP1 Protein (Over-Expression Lysate 6His, N-terminus) (Leu2-Lys597) - LS-G26737

Source:

HEK 293 Cells

Tag:

6His, N-terminus

Molecular Weight:

70 kDa

Price:

100 µg/$298

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PTPN6 / SHP1 Antibody LS-C752746

Antibody:

PTPN6 / SHP1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IP, WB

Format:

Unconjugated

Price:

100 µg/$351

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IHC-plus™ PTPN6 / SHP1 Antibody LS-B14929

(4.0) Rating

Antibody:

PTPN6 / SHP1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$460

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PTPN6 / SHP1 Antibody (HRP) LS-C318343

Antibody:

PTPN6 / SHP1 Rabbit anti-Human Polyclonal (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

HRP Conjugated

Price:

50 µg/$294; 100 µg/$360

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PTPN6 / SHP1 Antibody (Biotin) LS-C318344

Antibody:

PTPN6 / SHP1 Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

50 µg/$294; 100 µg/$360

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PTPN6 / SHP1 Antibody (FITC) LS-C318342

Antibody:

PTPN6 / SHP1 Rabbit anti-Human Polyclonal (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

FITC Conjugated

Price:

50 µg/$294; 100 µg/$360

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

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PTPN6 / SHP1 Antibody (phospho-Tyr564) LS-C199570

Antibody:

PTPN6 / SHP1 Rabbit anti-Human Polyclonal (pTyr564) Antibody

Reactivity:

Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

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PTPN6 / SHP1 Antibody (C-Terminus) LS-C413038

Antibody:

PTPN6 / SHP1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$341

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PTPN6 / SHP1 Antibody (phospho-Tyr536) LS-C808486

Antibody:

PTPN6 / SHP1 Rabbit anti-Human Polyclonal (pTyr536) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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PTPN6 / SHP1 Antibody LS-C806170

Antibody:

PTPN6 / SHP1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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PTPN6 / SHP1 Antibody LS-C801578

Antibody:

PTPN6 / SHP1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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PTPN6 / SHP1 Antibody (aa245-294, HRP) LS-C468632

Antibody:

PTPN6 / SHP1 Rabbit anti-Human Polyclonal (aa245-294) (HRP) Antibody

Reactivity:

Human, Monkey, Chimpanzee, Gibbon

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$469

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PTPN6 / SHP1 Antibody LS-C401020

Antibody:

PTPN6 / SHP1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

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PTPN6 / SHP1 Antibody LS-C38615

Antibody:

PTPN6 / SHP1 Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

ELISA, ICC, WB

Format:

Unconjugated

Price:

500 µg/$732

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PTPN6 / SHP1 Antibody LS-C38616

Antibody:

PTPN6 / SHP1 Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

ELISA, ICC, WB

Format:

Unconjugated

Price:

500 µg/$732

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PTPN6 / SHP1 Antibody LS-C38617

Antibody:

PTPN6 / SHP1 Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

ELISA, ICC, WB

Format:

Unconjugated

Price:

500 µg/$732

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PTPN6 / SHP1 Antibody LS-C38618

Antibody:

PTPN6 / SHP1 Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

ELISA, ICC, WB

Format:

Unconjugated

Price:

500 µg/$732

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