Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
IHC - Paraffin, Immunofluorescence, Western blot, ELISA
Mouse Monoclonal [clone 23E5] (IgG1) to Rat PTPN5 / STEP
Rat, Human, Mouse
Rat PTPN5 / STEP
Rat, Human, Mouse (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [23E5]
Specificity and Use
PTPN5 / STEP antibody was raised against a synthetic peptide of STEP46 (amino acids 57-74: MCTPGCNEEGFGYLVSPR). Percent identity by BLAST analysis: Mouse, Rat, Hamster, Rabbit (100%); Human, Gorilla, Gibbon, Monkey, Panda, Bovine, Bat, Horse, Pig (94%); Marmoset, Elephant, Dog (89%); Opossum (83%).
STEP61, STEP46, STEP38, and STEP20.
Ascites, 0.09% sodium azide
Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles.
Striatum-enriched phosphatase, a R7 receptor protein tyrosine phosphatase, is a component of the N-methyl-D-aspartate receptor (NMDAR) complex and has been suggested affect the development and maturation of the striatal neurons. STEP has been shown to regulate the activity of Fyn and may be one mechanism by which Fyn activity is decreased within the postsynaptic densities (PSDs) of striatal neurons. Alternative splicing of STEP produces cytosolic, transmembrane, and truncated isoforms.