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PTHLH / PTHRP

parathyroid hormone-like hormone

Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath (By similarity). Promotes colon cancer cell migration and invasion in an integrin alpha-6/beta-1-dependent manner through activation of Rac1.

Gene Name: parathyroid hormone-like hormone
Family/Subfamily: Hormone , not assigned-Hormone
Synonyms: PTHLH, Osteostatin, PTHR, PTH-related protein, PTHRP, BDE2, HHM, PLP, PTH-rP
Target Sequences: NM_002820 NP_002811.1 P12272

Publications (6)

1
Bone adaptation in response to treadmill exercise in young and adult mice. Gardinier JD, Rostami N, Juliano L, Zhang C. Bone reports. 2018 January;8:29-37. [Full Text Article] [PubMed:29379848] [PMC:PMC5787623] Related Antibodies: LS-B6787.
2
The tumor secretory factor ZAG promotes white adipose tissue browning and energy wasting. Sawsan Elattar, Manali Dimri, Ande Satyanarayana. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2018 September;32:4727-4743. [Full Text Article] [PubMed:29570397] [PMC:PMC6266632]
3
Expression of Signaling Molecules Involved in Embryonic Development of the Insertion Site Is Inadequate for Reformation of the Native Enthesis: Evaluation in a Novel Murine ACL Reconstruction Model. Xiang-Hua Deng, Amir Lebaschi, Christopher L Camp, Camila B Carballo, Nathan W Coleman, Jianchun Zong, Brian M Grawe, Scott A Rodeo. The Journal of bone and joint surgery. American volume. 2018 August;100:e102. [Full Text Article] [PubMed:30063598] [PMC:PMC6661256] Related Antibodies: LS-B12325.
4
Physiologic and molecular characterization of a novel murine model of metastatic head and neck cancer cachexia. Brennan Olson , Mason A Norgard, Peter R Levasseur, Xinxia Zhu, Daniel L Marks. Journal of cachexia, sarcopenia and muscle. 2021 Oct;;12:1312-1332. [Full Text Article] [PubMed:34231343] [PMC:PMC8517353]
5
Parathyroid Hormone-Related Protein Inhibition Blocks Triple-Negative Breast Cancer Expansion in Bone Through Epithelial to Mesenchymal Transition Reversal. Jiarong Li, Anne Camirand, Mahvash Zakikhani, Karine Sellin, Yubo Guo, XiaoRui Luan, Catalin Mihalcioiu, Richard Kremer. JBMR plus. 2022 June;6:e10587. [Full Text Article] [PubMed:35720668] [PMC:PMC9189913] Related Antibodies: LS-C408680.
6
Whole-body and adipose tissue metabolic phenotype in cancer patients. Lindsey J Anderson, Jonathan Lee, Barbara Anderson, Benjamin Lee, Dorota Migula, Adam Sauer, Nicole Chong, Haiming Liu, Peter C Wu, Atreya Dash, Yi-Ping Li, Jose M Garcia. Journal of cachexia, sarcopenia and muscle. 2022 April;13:1124-1133. [Full Text Article] [PubMed:35088949] [PMC:PMC8977952]
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Antibodies (110)
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PTHLH / PTHRP (162)
Human (52)
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PTHLH / PTHRP Antibody - Anti-PTHLH / PTHRP antibody IHC of human lung. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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PTHLH / PTHRP Rabbit anti-Mouse Polyclonal (aa77-126) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
PTHLH / PTHRP Antibody - Anti-PTHLH / PTHRP antibody IHC of human lung. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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PTHLH / PTHRP Rabbit anti-Mouse Polyclonal (aa77-126) (HRP) Antibody
Rabbit, Mouse, Goat, Dog, Guinea pig, Sheep, Bovine, Rat, Pig, Horse, Bat, Gibbon, Human, Monkey
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
PTHLH / PTHRP Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
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PTHLH / PTHRP Rabbit anti-Human Polyclonal (aa25-175) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
PTHLH / PTHRP Antibody - PTHLH / PTHRP antibody ARP33885_T100-NP_002811-PTHLH (parathyroid hormone-like hormone) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human kidney.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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PTHLH / PTHRP Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$397
PTHLH / PTHRP Antibody - PTHLH / PTHRP antibody ARP33885_T100-NP_002811-PTHLH (parathyroid hormone-like hormone) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human kidney.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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PTHLH / PTHRP Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody
Rabbit, Dog, Guinea pig, Pig, Horse, Bat, Gibbon, Human, Monkey, Chimpanzee
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$442
PTHLH / PTHRP Antibody - Western Blot (non-reducing) of PTHRP antibody
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PTHLH / PTHRP Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
50 µg/$356; 100 µg/$396
PTHLH / PTHRP Antibody - Western blot analysis of extracts of Mouse spleen cells.
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PTHLH / PTHRP Rabbit anti-Human Polyclonal Antibody
Mouse, Human
Flo, IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389; 200 µl/$503
PTHLH / PTHRP ELISA Kit
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Sandwich
96-Well Strip Plate
Human
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$940
PTHLH / PTHRP ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
PTHLH / PTHRP ELISA Kit
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Sandwich
96-Well Microplate
Human
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$771
PTHLH / PTHRP ELISA Kit
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Sandwich
96-Well Microplate
Rat
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
PTHLH / PTHRP Protein
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E. coli
His, N-Terminal
17.4 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
PTHLH / PTHRP ELISA Kit
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Sandwich
96-Well Strip Plate
Human
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
PTHLH / PTHRP ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$968
PTHLH / PTHRP ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
50 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
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PTHLH / PTHRP Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$357
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PTHLH / PTHRP Mouse anti-Human Monoclonal (aa37-175) (677939) Antibody
Human
IHC
Unconjugated
100 µg/$884
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PTHLH / PTHRP Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
50 µg/$294; 100 µg/$360
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PTHLH / PTHRP Goat anti-Human Polyclonal (aa53-86) Antibody
Mouse, Dog, Rat, Pig, Bat, Human
RIA
Unconjugated
20 µl/$460; 100 µl/$809
PTHLH / PTHRP Antibody - Western blot of recombinant PTHLH / PTHRP.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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PTHLH / PTHRP Rabbit anti-Chicken Polyclonal (aa38-176) Antibody
Chicken
WB
Unconjugated
100 µl/$306; 200 µl/$347; 500 µl/$484; 1 ml/$553; 2 ml/$737; 5 ml/$1,206
PTHLH / PTHRP Antibody - 1:100 staining mouse colon tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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PTHLH / PTHRP Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
PTHLH / PTHRP ELISA Kit
Select
Competitive EIA
96-Well Strip Plate
Mouse
12.35 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$782
PTHLH / PTHRP ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
PTHLH / PTHRP ELISA Kit
Select
Sandwich
96-Well Strip Plate
Dog
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$929
PTHLH / PTHRP ELISA Kit
Select
Sandwich
96-Well Strip Plate
Bovine
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$889
Viewing 1-25 of 162 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).