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PTGS2 / COX2 / COX-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis.
| Gene Name: | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) |
| Synonyms: | PTGS2, COX-2, Cyclooxygenase-2, COX2, Cyclooxygenase 2b, HCox-2, GRIPGHS, PGH synthase 2, PGHS-2, PHS II, PHS-2, Prostaglandin H2 synthase 2, PGG/HS, Prostaglandin G/H synthase 2 |
| Target Sequences: | NM_000963 NP_000954.1 P35354 |
Publications (7)
1
Interleukin-1beta-induced cyclooxygenase-2 expression requires activation of both c-Jun NH2-terminal kinase and p38 MAPK signal pathways in rat renal mesangial cells. Guan Z, Buckman SY, Miller BW, Springer LD, Morrison AR. The Journal of biological chemistry. 1998 273:28670-6.
[PubMed:9786861]
Related Antibodies: LS-B410.
2
Induction of NAD(+)-linked 15-hydroxyprostaglandin dehydrogenase expression by androgens in human prostate cancer cells. Tong M, Tai HH. Biochemical and biophysical research communications. 2000 276:77-81.
[PubMed:11006085]
Related Antibodies: LS-B410.
3
Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer's Disease. Lee JY, Han SH, Park MH, Baek B, Song IS, Choi MK, Takuwa Y, Ryu H, Kim SH, He X, Schuchman EH, Bae JS, Jin HK. Nature communications. 2018 April;9:1479. [Full Text Article]
[PubMed:29662056]
[PMC:PMC5902554]
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PTGS2 / COX2 / COX-2 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Sheep, Bovine, Rat, Pig, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
PTGS2 / COX2 / COX-2 Rabbit anti-Rat Monoclonal (C-Terminus) (SP21) Antibody
Human
IHC, IHC-P
Unconjugated
500 µl/$463
Cancer Pathology
Cancer
PTGS2 / COX2 / COX-2 Goat anti-Human Polyclonal (aa550-600) Antibody
Mouse, Sheep, Rat, Human
ICC, IHC, IHC-P, WB
Unconjugated
1 Each/$485
PTGS2 / COX2 / COX-2 Rabbit anti-Mouse Polyclonal Antibody
Mouse, Sheep, Rat, Human
IHC, IHC-P, WB
Unconjugated
1 Each/$431
PTGS2 / COX2 / COX-2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$495
PTGS2 / COX2 / COX-2 Rabbit anti-Human Polyclonal (aa589-604) Antibody
Human
IHC, IHC-Fr, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
PTGS2 / COX2 / COX-2 Rabbit anti-Human Polyclonal (aa554-604) Antibody
Human
IHC, IHC-P, IP, WB
Unconjugated
10 µg/$295; 100 µl/$514
PTGS2 / COX2 / COX-2 Rabbit anti-Mouse Polyclonal (FITC) Antibody
Mouse, Rat, Human
Flo, IF, WB
FITC Conjugated
1 Each/$457
PTGS2 / COX2 / COX-2 Mouse anti-Human Monoclonal (aa18-260) (OTI10H5) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
Sandwich
96-Well Strip Plate
Mouse
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
E. coli
6His, N-terminus
70.9 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$768
Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$764
PTGS2 / COX2 / COX-2 Mouse anti-Human Monoclonal (aa580-599) (FITC) Antibody
Human
Flo
FITC Conjugated
1 Each/$763
Sandwich
96-Well Strip Plate
Human
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$818
PTGS2 / COX2 / COX-2 Goat anti-Human Polyclonal (aa592-604) Antibody
Dog, Sheep, Bovine, Pig, Horse, Human, Monkey
IF, Peptide-ELISA, WB
Unconjugated
100 µg/$503
PTGS2 / COX2 / COX-2 Mouse anti-Human Monoclonal (aa18-260) (OTI5F12) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
Wheat Germ Extract
GST
92.18 kDa
2 µg/$439
PTGS2 / COX2 / COX-2 Rabbit anti-Rat Polyclonal (C-Terminus) Antibody
Mouse, Rat, Human
IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
500 µl/$1,032
PTGS2 / COX2 / COX-2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$357
PTGS2 / COX2 / COX-2 Rabbit anti-Human Polyclonal (aa363-391) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
PTGS2 / COX2 / COX-2 Rabbit anti-Mouse Polyclonal Antibody
Mouse
ICC, IHC, IHC-P, WB
Unconjugated
1 Each/$431
Sandwich
96-Well Strip Plate
Rat
1.56 - 100 U/l
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
Sandwich
96-Well Strip Plate
Mouse
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$782
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