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Anti-PTGS2 / COX2 / COX-2 Antibody (clone COX 229) IHC-plus™ LS-B3296

Note: This antibody replaces LS-C22397

100% Guaranteed 100% Guaranteed
Mouse Monoclonal [clone COX 229] (IgG1,k) to Human PTGS2 / COX2 / COX-2
IHC - Paraffin, IHC - Frozen


Human PTGS2 / COX2 / COX-2
Human (tested or 100% immunogen sequence identity)
IgG1,k Monoclonal [COX 229]


IHC - Paraffin (10 µg/ml), IHC - Frozen

Specificity and Use

PTGS2 / COX2 / COX-2 antibody was raised against synthetic peptide from human COX-2 Expected Staining Pattern: Cytoplasm.
Recognizes human COX-2.
Immunohistochemistry: LS-B3296 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-B3296 was determined to be 10 ug/ml. Positive control: Colon carcinoma.


PBS, pH 7.4, 1% BSA, 0.1% sodium azide.
Long term: -20°C; Short term: +4°C; Avoid freeze-thaw cycles.
For research use only.

About PTGS2 / COX2 / COX-2

P35354 NM_000963 NP_000954.1

PTGS2 Antibody, COX-2 Antibody, Cyclooxygenase-2 Antibody, COX2 Antibody, Cyclooxygenase 2b Antibody, HCox-2 Antibody, GRIPGHS Antibody, PGH synthase 2 Antibody, PGHS-2 Antibody, PHS II Antibody, PHS-2 Antibody, Prostaglandin H2 synthase 2 Antibody, PGG/HS Antibody, Prostaglandin G/H synthase 2 Antibody

Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis.


Anti-COX-2 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3296 concentration 10 ug/ml.


Anti-COX-2 antibody IHC of human small intestine, ganglion cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3296 concentration 10 ug/ml.

Requested From: United States
Date Requested: 10/13/2015

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