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Anti-PTGS2 / COX2 / COX-2 Antibody (C-Terminus) IHC-plus™ LS-B410

Note: This antibody replaces LS-C18875


Wt. Vol. Conc. Price
- 50 µl - $395
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)

Most Popular PTGS2 / COX2 / COX-2 Antibodies

Anti-PTGS2 / COX2 / COX-2 Antibody (clone COX 229) IHC-plus™ LS-B3296
Mouse Monoclonal [clone COX 229] (IgG1,k) to Human PTGS2 / COX2 / COX-2
IHC - Paraffin, IHC - Frozen
Immunohistochemistry Image
Anti-PTGS2 / COX2 / COX-2 Antibody (C-Terminus, clone SP21) LS-C210609
Rabbit Monoclonal [clone SP21] (IgG) to Rat PTGS2 / COX2 / COX-2
Rat, Human
IHC - Paraffin
Immunohistochemistry Image
Anti-PTGS2 / COX2 / COX-2 Antibody (aa589-604) LS-C312879
Rabbit Polyclonal (IgG) to Human PTGS2 / COX2 / COX-2
Human, Monkey, Bovine, Goat, Pig, Sheep
IHC - Paraffin, IHC - Frozen, Western blot
Immunohistochemistry Image

100% Guaranteed 100% Guaranteed Publications Publications (2)
Rabbit Polyclonal to Human PTGS2 / COX2 / COX-2
Human, Mouse, Rat
IHC - Paraffin, Western blot, ELISA


Human PTGS2 / COX2 / COX-2
Human, Mouse, Rat (tested or 100% immunogen sequence identity)
Sterile filtered


  • IHC - Paraffin (1:500)
  • Western blot (1:5000 - 1:10000)
  • ELISA (1:10000 - 1:50000)

Specificity and Use

PTGS2 / COX2 / COX-2 antibody was raised against fusion protein from human PTGS2 / COX-2.
GST fusion protein, the epitope of which maps to the carboxy-terminus of human Cox-2.
Immunohistochemistry: LS-B410 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-B410 was determined to be 1:500.


0.01% sodium azide.
+4°C or -20°C, Avoid repeated freezing and thawing.
For research use only.

Publications (2)

Interleukin-1beta-induced cyclooxygenase-2 expression requires activation of both c-Jun NH2-terminal kinase and p38 MAPK signal pathways in rat renal mesangial cells. Guan Z, Buckman SY, Miller BW, Springer LD, Morrison AR. The Journal of biological chemistry. 1998 273:28670-6. [PubMed:9786861]
Induction of NAD(+)-linked 15-hydroxyprostaglandin dehydrogenase expression by androgens in human prostate cancer cells. Tong M, Tai HH. Biochemical and biophysical research communications. 2000 276:77-81. [PubMed:11006085]

About PTGS2 / COX2 / COX-2

P35354 NM_000963 NP_000954.1

PTGS2 Antibody, COX-2 Antibody, Cyclooxygenase-2 Antibody, COX2 Antibody, Cyclooxygenase 2b Antibody, HCox-2 Antibody, GRIPGHS Antibody, PGH synthase 2 Antibody, PGHS-2 Antibody, PHS II Antibody, PHS-2 Antibody, Prostaglandin H2 synthase 2 Antibody, PGG/HS Antibody, Prostaglandin G/H synthase 2 Antibody

Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis.


Anti-COX-2 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B410 dilution 1:500.

Western blot

Western blot
Anti-Cox2 Antibody - Western Blot. anti-Cox2 is shown to detect Cox-2 present in Cox-2 transfected Sf9 cell extract (lane 1) and IL-1beta induced WISH cell extract (lane 2). Detection occurs using a 1:10000 dilution of antibody followed by 1:10000 dilution of HRP Goat-a-Rabbit with visualization via ECL. Film exposure approximately 1. Other detection systems will yield similar results.

Western blot

Western blot
Anti-Cox2 is shown to detect Cox-2 present in Cox-2 transfected Sf9 cell extract (lane 1) and IL-1b induced WISH cell extract (lane 2). Detection occurs using a 1:10,000 dilution of antibody.

Requested From: United States
Date Requested: 10/27/2016

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