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PTGS1 / COX-1

prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)

Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells.

Gene Name: prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
Synonyms: PTGS1, COX1, Cyclooxygenase-1, COX-1, PES-1, PGH synthase 1, Prostaglandin G/H synthase 1, PTGHS, COX3, PCOX1, PGG/HS, PGHS-1, PGHS1, PHS 1, PHS1, Prostaglandin H2 synthase 1
Target Sequences: NM_000962 NP_000953.2 P23219

Publications (1)

1
Inhibition of Pro-inflammatory and Anti-apoptotic Biomarkers during Experimental Oral Cancer Chemoprevention by Dietary Black Raspberries. Oghumu S, Casto BC, Ahn-Jarvis J, Weghorst LC, Maloney J, Geuy P, Horvath KZ, Bollinger CE, Warner BM, Summersgill KF, Weghorst CM, Knobloch TJ. Frontiers in immunology. 2017 October;8:1325. [Full Text Article] [PubMed:29109723] [PMC:PMC5660285]

☰ Filters
Antibodies (90)
ELISA Kits (23)
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PTGS1 / COX-1 (123)
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PTGS1 / COX-1 Antibody - Anti-PTGS1 / COX-1 antibody IHC of human vessel. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
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Neuroscience
PTGS1 / COX-1 Rabbit anti-Human Polyclonal (aa550-599) Antibody
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$440
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PTGS1 / COX-1 Mouse anti-Human Monoclonal Antibody
Rabbit, Guinea pig, Sheep, Bovine, Human
ELISA, IHC
Unconjugated
1 ml/$626
PTGS1 / COX-1 Antibody - Anti-PTGS1 / COX-1 antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.
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PTGS1 / COX-1 Goat anti-Human Polyclonal (aa617-630) Antibody
Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
PTGS1 / COX-1 Antibody - Human Skin: Formalin-Fixed, Paraffin-Embedded (FFPE)
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PTGS1 / COX-1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Rat, Human
IHC-P, WB
Unconjugated
50 µl/$460
PTGS1 / COX-1 ELISA Kit
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Sandwich
96-Well Microplate
Human
0.63 - 40 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$771
PTGS1 / COX-1 Protein - Recombinant Prostaglandin Endoperoxide Synthase 1 By SDS-PAGE
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E. coli
His, N-Terminal
30.4 kDa
10 µg/$291; 50 µg/$502; 100 µg/$802; 200 µg/$1,002; 1 mg/$2,144; 500 µg/$1,668; 5 mg/$3,501; 2 mg/$2,334
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PTGS1 / COX-1 Mouse anti-Human Monoclonal (PE) (CX111) Antibody
Mouse, Sheep, Bovine, Rat, Human
Flo, IF
PE Conjugated
1 Each/$457
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PTGS1 / COX-1 Mouse anti-Human Monoclonal Antibody
Mouse, Sheep, Rat, Human
ELISA, IF, IHC, IHC-Fr, IHC-P, WB
Unconjugated
100 µg/$740
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PTGS1 / COX-1 Mouse anti-Human Monoclonal (HRP) Antibody
Mouse, Sheep, Rat, Human
ELISA, IF, IHC, WB
HRP Conjugated
100 µl/$982
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PTGS1 / COX-1 Mouse anti-Human Monoclonal (Biotin) Antibody
Mouse, Sheep, Rat, Human
ELISA, IF, IHC, WB
Biotin Conjugated
100 µl/$982
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PTGS1 / COX-1 Mouse anti-Human Monoclonal (FITC) Antibody
Mouse, Sheep, Rat, Human
ELISA, IF, IHC, WB
FITC Conjugated
100 µl/$982
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PTGS1 / COX-1 Mouse anti-Human Monoclonal (PE) Antibody
Mouse, Sheep, Rat, Human
ELISA, IF, IHC, WB
PE Conjugated
100 µl/$982
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PTGS1 / COX-1 Mouse anti-Human Monoclonal (APC) Antibody
Mouse, Sheep, Rat, Human
ELISA, IF, IHC, WB
APC Conjugated
100 µl/$982
PTGS1 / COX-1 Antibody - 1:200 staining human brain tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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PTGS1 / COX-1 Rabbit anti-Human Polyclonal Antibody
Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
PTGS1 / COX-1 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
PTGS1 / COX-1 Protein - 12.5% SDS-PAGE of human PTGS1 stained with Coomassie Blue
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Wheat Germ Extract
GST
95.1 kDa
2 µg/$439
PTGS1 / COX-1 Antibody - PTGS1 / COX1 / COX-1 antibody. IHC(P): Human Intestinal Cancer Tissue.
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PTGS1 / COX-1 Rabbit anti-Human Polyclonal (aa318-599) Antibody
Rat, Human
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
PTGS1 / COX-1 Antibody - Anti-PTGS1 / COX-1 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 15 ug/ml.
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PTGS1 / COX-1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC, IHC-P
Unconjugated
500 µl/$460
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PTGS1 / COX-1 Rabbit anti-Mouse Polyclonal (N-Terminus) Antibody
Mouse, Dog, Human
ELISA, WB
Unconjugated
100 µg/$832
PTGS1 / COX-1 Antibody - Transfected 293T cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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PTGS1 / COX-1 Rabbit anti-Human Polyclonal (aa218-267) Antibody
Human
WB
Unconjugated
100 µl/$424
PTGS1 / COX-1 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
PTGS1 / COX-1 Antibody - Immunocytochemistry/Immunofluorescence analysis using Rabbit Anti-Cyclooxygenase 1 Polyclonal Antibody. Tissue: Colon carcinoma cell line (RKO). Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Rabbit Anti-Cyclooxygenase 1 Polyclonal Antibody  at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Rabbit ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000, 1:5000 for 60 min at RT, 5 min at RT. Localization: Microsome Membrane, Endoplasmic Reticulum Membrane, Membrane. Magnification: 60X. (A) DAPI nuclear stain. (B) Phalloidin Texas Red F-Actin stain. (C) Cyclooxygenase 1 Antibody. (D) Composite.
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PTGS1 / COX-1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, WB
Unconjugated
100 µg/$442
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PTGS1 / COX-1 Rabbit anti-Human Polyclonal (aa272-282) Antibody
Sheep, Bovine, Horse, Human
ICC, IHC, WB
Unconjugated
200 µl/$737
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PTGS1 / COX-1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$331
PTGS1 / COX-1 Antibody - Western blot of Cox-1 antibody
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PTGS1 / COX-1 Rabbit anti-Human Polyclonal (520-600 aa, C-terminal) Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
Viewing 1-25 of 123 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).