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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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PTGER3 / EP3 Antibody IHC‑plus™ LS‑B6944
Note: This antibody replaces LS-C146660
EP3 antibody LS-B6944 is an unconjugated rabbit polyclonal antibody to human EP3 (PTGER3). Validated for ICC, IHC and WB. Tested on 20 paraffin-embedded human tissues.
Catalog
Size
Price
LS-B6944-1
1 ea
Unavailable

Popular PTGER3 / EP3 Products

Anti-PTGER3 / EP3 antibody LS-A973 IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Species: Human, Monkey, Mouse, Rat, Bat, Horse, Rabbit
Applications: IHC, IHC - Paraffin, ELISA
Anti-PTGER3 / EP3 antibody LS-A974 IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Species: Human, Monkey, Bovine, Horse, Pig
Applications: IHC, IHC - Paraffin
Anti-PTGER3 / EP3 antibody IHC of human brain, glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Species: Human, Monkey, Bat
Applications: IHC, IHC - Paraffin
IHC of paraffin-embedded human brain tissue, using PE2R3 Antibody. The picture on the right is treated with the synthesized peptide.
Species: Human
Applications: IHC, IHC - Paraffin, Immunofluorescence, Western blot, Peptide Enzyme-Linked Immunosorbent Assay

Product Description

EP3 antibody LS-B6944 is an unconjugated rabbit polyclonal antibody to human EP3 (PTGER3). Validated for ICC, IHC and WB. Tested on 20 paraffin-embedded human tissues.
About PTGER3 / EP3
Receptor for prostaglandin E2 (PGE2); the EP3 receptor may be involved in inhibition of gastric acid secretion, modulation of neurotransmitter release in central and peripheral neurons, inhibition of sodium and water reabsorption in kidney tubulus and contraction in uterine smooth muscle. The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G-I proteins, and to an elevation of intracellular calcium. P43115 NM_000957 NP_000948.2

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Specifications

Target
Human PTGER3 / EP3
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Predicted
Monkey, Bat, Horse, Rabbit (at least 90% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Unconjugated
Purification
Affinity purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (5 µg/ml)
  • ICC (1 - 2 µg/ml)
  • Western blot (1 - 2 µg/ml)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
PTGER3 / EP3 antibody was raised against human EP3 receptor amino acids 308-327 (NQTSVEHCKTHTEKQKECNF). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Marmoset (100%); Monkey, Bat, Panda, Horse (95%); Rabbit (90%); Elephant (85%); Bovine, Pig (80%).
Specificity
The EP3 receptor appears to be expressed at low levels in many tissues and cell types, potentially making detection by immunochemical techniques difficult. Does not cross react with EP1, EP2 and EP4 receptors.
Presentation
TBS, pH 7.4, containing 50% glycerol, 0.1% BSA, and 0.02% sodium azide
Storage
Short term 4°C, long term aliquot and store at -20°C, avoid freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Images


Immunohistochemistry

Anti-PTGER3 / EP3 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6944 concentration 5 ug/ml.
Anti-PTGER3 / EP3 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6944 concentration 5 ug/ml.

Western blot

Western blot of PTGER3 / EP3 antibody LS-B6944.
Western blot of PTGER3 / EP3 antibody LS-B6944.

Immunohistochemistry

Anti-PTGER3 / EP3 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6944 concentration 5 ug/ml.
Anti-PTGER3 / EP3 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6944 concentration 5 ug/ml.

Western blot

Western blot of PTGER3 / EP3 antibody LS-B6944.
Western blot of PTGER3 / EP3 antibody LS-B6944.

Immunohistochemistry

Anti-PTGER3 / EP3 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6944 concentration 5 ug/ml.
Anti-PTGER3 / EP3 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6944 concentration 5 ug/ml.

Western blot

Western blot of PTGER3 / EP3 antibody LS-B6944.
Western blot of PTGER3 / EP3 antibody LS-B6944.

Immunohistochemistry

Anti-PTGER3 / EP3 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6944 concentration 5 ug/ml.
Anti-PTGER3 / EP3 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6944 concentration 5 ug/ml.

Western blot

Western blot of PTGER3 / EP3 antibody LS-B6944.
Western blot of PTGER3 / EP3 antibody LS-B6944.


Requested From: 
Date Requested: 6/23/2018

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