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Anti-PSENEN / PEN-2 Antibody IHC-plus™ LS-B299

Note: This antibody replaces LS-C2835, LS-C92306


Wt. Vol. Conc. Price
- 50 µl - $395
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)

Most Popular PSENEN / PEN-2 Antibodies

Anti-PSENEN / PEN-2 Antibody (N-Terminus) IHC-plus™ LS-B3207
Rabbit Polyclonal to Human PSENEN / PEN-2
Human, Mouse, Rat
IHC - Paraffin, Western blot, ELISA
Immunohistochemistry Image
Anti-PSENEN / PEN-2 Antibody (C-Terminus) LS-C135520
Rabbit Polyclonal to Human PSENEN / PEN-2
Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Guinea pig, Horse, Pig, Rabbit, Xenopus, Zebrafish
Western blot
Western blot Image
Anti-PSENEN / PEN-2 Antibody (aa20-69) LS-C145247
Rabbit Polyclonal to Mouse PSENEN / PEN-2
Mouse, Human, Monkey, Bat, Dog, Guinea pig, Horse, Pig, Rabbit
Western blot
Western blot Image

100% Guaranteed 100% Guaranteed
Rabbit Polyclonal to Human PSENEN / PEN-2
Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Horse, Pig, Rabbit
IHC - Paraffin, Western blot, Immunoprecipitation


Human PSENEN / PEN-2
Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Horse, Pig, Rabbit (tested or 100% immunogen sequence identity)


  • IHC - Paraffin (1:500)
  • Western blot (1:1000 - 1:2500)
  • Immunoprecipitation (1:50 - 1:100)

Specificity and Use

PSENEN / PEN-2 antibody was raised against synthetic peptide corresponding to amino acid residues FQIYRPRWGALGDYLSFTIPLGTP of the human protein. Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Elephant, Panda, Dog, Bat, Bovine, Horse, Rabbit, Pig (100%); Opossum (83%).
Rabbit Polyclonal to PEN2 (CR8).
Immunohistochemistry: LS-B299 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-B299 was determined to be 1:500.


Serum, 0.05% sodium azide.
Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
For research use only.

About PSENEN / PEN-2

Q9NZ42 NM_172341 NP_758844.1

PSENEN Antibody, Gamma-secretase subunit PEN-2 Antibody, MSTP064 Antibody, Presenilin enhancer protein 2 Antibody, MDS033 Antibody, PEN-2 Antibody, PEN2 Antibody

Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease.


Anti-PEN2 antibody IHC of human lung. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B299 dilution 1:500.

Requested From: United States
Date Requested: 10/26/2016

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