Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Rabbit Polyclonal (IgG) to Human PSEN1 / Presenilin 1
IHC, Immunofluorescence, Western blot, Flow Cytometry
Rat Monoclonal (IgG) to Human PSEN1 / Presenilin 1
IHC, Western blot, Immunoprecipitation, ELISA
Human PSEN1 / Presenilin 1
Human (tested or 100% immunogen sequence identity)
Tissue culture supernatant
Western blot (1:250 - 1:500)
Specificity and Use
A fusion protein antigen containing the N-terminal of human PS-1 (residues 21-80) fused to GST.
Recognizes human Presenilin 1.
Suitable for use in Immunohistochemistry, Western Blot, Immunoprecipitation and ELISA. Western Blot: 1:250-1:500. Recommend blocking buffer is TBS containing 5% non fat milk and 0.01% Tween 20. It is recommended that you also dilute the antibody in this blocking buffer. Incubate for 1 to 2 hours at RT or overnight at 4?C.
0.1% sodium azide.
Short term: +4°C; Long term: Add glycerol (40-50%) -20°C.
Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane.