Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
(applications tested for the base form of this product only)
Specificity and Use
Proximal sequence element (PSE1) of the human U1 small nuclear RNA extracted from human placenta.
Recognizes the large alpha subunit (~80-90kD) of placental PSE1 and human Ku in solution and when bound to DNA.
Western blot and electrophoretic mobility (gel shift) assays for identifying PSE1 or Ku. Used to immuno-deplete Ku protein from protein mixtures prior to specific DNA affinity chromatography. Dilute in PBS or medium which is identical to that used in the assay system.
PBS, pH 7.4.
For research use only.
About Proximal Sequence Element (PSE1)/ Ku Protein