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Proenkephalin / PENK
proenkephalin
Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. PENK(114-133) and PENK(237-258) increase glutamate release in the striatum. PENK(114-133) decreases GABA concentration in the striatum.
| Gene Name: | proenkephalin |
| Family/Subfamily: | Endogenous opioids , not assigned-Endogenous opioids |
| Synonyms: | PENK, Enkephalin A, Met enkephalin, Preproenkephalin, Proenkephalin, Proenkephalin-A |
| Target Sequences: | NM_006211 NP_006202.1 P01210 |
Publications (6)
1
Classes and continua of hippocampal CA1 inhibitory neurons revealed by single-cell transcriptomics. Harris KD, Hochgerner H, Skene NG, Magno L, Katona L, Bengtsson Gonzales C, Somogyi P, Kessaris N, Linnarsson S, Hjerling-Leffler J. PLoS biology. 2018 June;16:e2006387. (Rat)
[Full Text Article]
[PubMed:29912866]
[PMC:PMC6029811]
2
Dynamic postnatal development of the cellular and circuit properties of striatal D1 and D2 spiny projection neurons. Krajeski RN, Macey-Dare A, van Heusden F, Ebrahimjee F, Ellender TJ. The Journal of physiology. 2019 November;597:5265-5293. [Full Text Article]
[PubMed:31531863]
[PMC:PMC6900874]
3
Novel bifunctional hybrid compounds designed to enhance the effects of opioids and antagonize the pronociceptive effects of nonopioid peptides as potent analgesics in a rat model of neuropathic pain. Anna Piotrowska, Joanna Starnowska-Sokól, Wioletta Makuch, Joanna Mika, Ewa Witkowska, Dagmara Tymecka, Angelika Ignaczak, Beata Wilenska, Aleksandra Misicka, Barbara Przewlocka. Pain. 2021 February;162:432-445. [Full Text Article]
[PubMed:32826750]
[PMC:PMC7808367]
Related Antibodies: LS-B15645.
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Neuroscience
Proenkephalin / PENK Rabbit anti-Human Polyclonal (aa 25-267) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
Proenkephalin / PENK Mouse anti-Human Monoclonal (9E7) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$423
Sandwich
96-Well Strip Plate
Human
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$834
Sandwich
96-Well Strip Plate
Mouse
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$854
Proenkephalin / PENK Goat anti-Mouse Polyclonal (aa84-94) Antibody
Mouse, Rat
IHC-Fr, Peptide-ELISA
Unconjugated
100 µg/$503
Proenkephalin / PENK Rabbit anti-Human Polyclonal (aa143-192) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
Proenkephalin / PENK Rabbit anti-Human Polyclonal (aa145-174) Antibody
Human
Flo, IHC, IHC-P
Unconjugated
400 µl/$393
Proenkephalin / PENK Rabbit anti-Cat Polyclonal Antibody
Rat, Pig, Cat
IF, IHC, IHC-Fr, IHC-P
Unconjugated
50 µl/$952
Proenkephalin / PENK Mouse anti-Rat Monoclonal (C-Terminus) Antibody
Rabbit, Guinea pig, Rat, Hamster
ICC, IHC, IHC-Fr
Unconjugated
100 µl/$748
Proenkephalin / PENK Mouse anti-Human Monoclonal (C-Terminus) Antibody
Human
IHC, RIA
Unconjugated
500 µl/$1,167
Proenkephalin / PENK Rabbit anti-Rat Polyclonal Antibody
Rat
IF
Unconjugated
50 µl/$786
Proenkephalin / PENK Rabbit anti-Human Polyclonal (FITC) Antibody
Human
WB
FITC Conjugated
100 µl/$348; 200 µl/$407; 500 µl/$605; 1 ml/$755; 2 ml/$993; 5 ml/$1,716
Proenkephalin / PENK Rabbit anti-Human Polyclonal Antibody
ELISA, ICC, IHC, RIA
Unconjugated
100 µl/$487
Proenkephalin / PENK Rabbit anti-Human Polyclonal (aa145-174) (Biotin) Antibody
Human
ELISA, Flo, IHC, WB
Biotin Conjugated
200 µl/$952
Proenkephalin / PENK Rabbit anti-Human Polyclonal (aa145-174) (FITC) Antibody
Human
ELISA, Flo, IHC, WB
FITC Conjugated
200 µl/$952
Proenkephalin / PENK Rabbit anti-Human Polyclonal (aa145-174) (Azide-free) (HRP) Antibody
Human
ELISA, Flo, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
Proenkephalin / PENK Rabbit anti-Human Polyclonal (aa145-174) (PE) Antibody
Human
ELISA, Flo, IHC, WB
PE Conjugated
200 µl/$952
Proenkephalin / PENK Rabbit anti-Human Polyclonal (aa145-174) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
29.2kD
50 µg/$534
Sandwich
96-Well Strip Plate
Mouse
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$783
Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
Wheat Germ Extract
GST
55.11 kDa
2 µg/$439
Fast Shipping
Proenkephalin / PENK Rabbit anti-Human Polyclonal Antibody
IHC-P
Unconjugated
50 µg/$460
Fast Shipping
Proenkephalin / PENK Rabbit anti-Human Polyclonal Antibody
IHC-P
Unconjugated
50 µg/$460
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