Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Human (tested or 100% immunogen sequence identity)
IHC - Paraffin
IHC - Frozen (1:10)
Flow Cytometry (1:10)
Specificity and Use
PROCR / EPCR antibody was raised against tail base human EPCR-positive RE-1 cells.
Recognizes human EPCR. Inhibits thrombin-dependent protein C activation and blocks APC-mediated signalling.
Suitable for use in Flow Cytometry, Immunohistochemistry (frozen), and inhibition of biological activity. Flow Cytometry: 1:10. Immunohistochemistry (frozen): 1:10. For inhibition of biological activity in vitro a dilution of 1:5 is advised as start concentration.
PBS, 0.1% BSA
May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C.
PROCR Antibody, Activated protein C receptor Antibody, CD201 Antibody, CD201 antigen Antibody, Centrocyclin Antibody, CCD41 Antibody, Endothelial protein C receptor Antibody, APC receptor Antibody, BA42O4.2 Antibody, CCCA Antibody, EPCR Antibody
PROCR / EPCR is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy. The encoded protein may also play a role in malarial infection and has been associated with cancer.