Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Human (tested or 100% immunogen sequence identity)
Specificity and Use
PROC / Protein C antibody was raised against protein C purified from human plasma.
Recognizes human protein C, a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. It is converted to activated protein C by the thrombomodulin/thrombin complex on the phospholipd surface of endothelial cells, monocytes and platelets.
PROC Antibody, Anticoagulant protein C Antibody, Blood coagulation factor XIV Antibody, Autoprothrombin IIA Antibody, Protein C Antibody, PROC1 Antibody, Vitamin K-dependent protein C Antibody, THPH3 Antibody, THPH4 Antibody
PROC / Protein C is a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.