Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
IHC - Paraffin, ICC, Immunofluorescence, Western blot
Mouse Monoclonal (IgG) to Human PROC / Protein C
Human PROC / Protein C
Human (tested or 100% immunogen sequence identity)
Specificity and Use
Protein C (PC) purified from human plasma.
Recognizes an epitope on the heavy chain of human PC. There is good reactivity to unactivated and to activated PC, but not to activated PC in complex with Protein C Inhibitor (APC-PCI) or a1antitrypsin (APC-AT) as measured by ELISA. There is no apparent calcium dependence. No reaction was obtained with PC-deficient plasma.
Suitable for use in ELISA.
10 mM HEPES, pH 7.4, 0.1 M sodium chloride, 50% glycerol.
Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PROC Antibody, Anticoagulant protein C Antibody, Blood coagulation factor XIV Antibody, Autoprothrombin IIA Antibody, Protein C Antibody, PROC1 Antibody, Vitamin K-dependent protein C Antibody, THPH3 Antibody, THPH4 Antibody
PROC / Protein C is a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.