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PRNP / PrP / Prion
prion protein
PRNP / PrP / Prion is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. An overlapping open reading frame has been found for this gene that encodes a smaller, structurally unrelated protein, AltPrp. Alternative splicing results in multiple transcript variants.
| Gene Name: | prion protein |
| Synonyms: | PRNP, AltPrP, ASCR, CD230 antigen, CJD, KURU, Major prion protein, p27-30, Prion, Prion-related protein, PRIP, Prion protein (p27-30), PrP, PrP33-35C, BSE, CD230, Prion protein, PrP27-30, PrPc |
| Target Sequences: | NM_000311 NP_000302.1 P04156 |
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PRNP / PrP / Prion
(89)
Reactivity
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(45)
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(49)
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rabbit
(46)
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(16)
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(1)
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(18)
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(2)
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(13)
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monoclonal mc
(16)
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(48)
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(1)
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(1)
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(1)
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(12)
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(3)
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(2)
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(3)
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(7)
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(2)
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(2)
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(7)
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(7)
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(4)
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(32)
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aa23-230
(16)
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(4)
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(2)
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(2)
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(1)
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(1)
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(1)
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(1)
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(1)
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(1)
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(1)
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(1)
Publications
No
(89)
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Cell Culture Supernatants
(3)
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(8)
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(5)
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(5)
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(10)
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(2)
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(4)
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(2)
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(1)
Species
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(6)
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(1)
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(2)
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(5)
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(1)
Wheat Germ Extract
(2)
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(1)
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Purified
(3)
Low Endotoxin Level
Low endotoxin level
(2)
E. coli
His, N-Terminal
26.8 kDa
10 µg/$284; 50 µg/$462; 200 µg/$922; 1 mg/$2,042; 5 mg/$3,221; 2 mg/$2,231
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$818
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Tissue Homogenates
1 Plate/$798
Sandwich
96-Well Strip Plate
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
E. coli
His
20 µg/$361; 100 µg/$739; 4 µg/$261
Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
PRNP / PrP / Prion Rabbit anti-Human Polyclonal (T16-R) Antibody
Mouse, Sheep, Bovine, Rat, Human
ELISA, IHC, IHC-P, IP, WB
Unconjugated
50 µl/$485
Yeast
His
24.25 kD
100 µg/$499; 20 µg/$364; 1 mg/$1,683
Neuroscience
PRNP / PrP / Prion Mouse anti-Human Monoclonal (EM-20) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µg/$440
PRNP / PrP / Prion Rabbit anti-Mouse Polyclonal (aa91-140) Antibody
Mouse, Human
WB
Unconjugated
100 µl/$424
PRNP / PrP / Prion Goat anti-Human Polyclonal (aa79-97) Antibody
Human
IHC
Unconjugated
100 µl/$295
PRNP / PrP / Prion Rabbit anti-Human Polyclonal (aa23-230) (Biotin) Antibody
Mouse, Rat, Human
WB
Biotin Conjugated
100 µl/$313; 200 µl/$357; 500 µl/$503; 1 ml/$576; 2 ml/$788; 5 ml/$1,279
PRNP / PrP / Prion Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
HEK 293 Cells
Human IgG Fc, C-terminus
SDS-PAGE
Less than 1.0 EU/µg protein (determined by LAL method).
The recombinant human PRNP/Fc comprises 448 amino acids and has a predicted molecular mass of 49.7 kDa. The apparent molecular mass of the protein is approximately 57.4 kDa in SDS-PAGE under reducing conditions.
100 µg/$480
E. coli
His, N-Terminal
26.6 kDa
10 µg/$280; 50 µg/$437; 100 µg/$700; 200 µg/$872; 1 mg/$1,978; 500 µg/$1,519; 5 mg/$3,053; 2 mg/$2,164
PRNP / PrP / Prion Mouse anti-Human Monoclonal (HRP) Antibody
Hamster, Cat, Human
ELISA, IHC, IP, WB
HRP Conjugated
100 µl/$1,144
PRNP / PrP / Prion Mouse anti-Human Monoclonal (Biotin) Antibody
Hamster, Cat, Human
ELISA, IHC, IP, WB
Biotin Conjugated
100 µl/$1,144
PRNP / PrP / Prion Mouse anti-Human Monoclonal (FITC) Antibody
Hamster, Cat, Human
ELISA, IHC, IP, WB
FITC Conjugated
100 µl/$1,144
PRNP / PrP / Prion Mouse anti-Human Monoclonal (APC) Antibody
Hamster, Cat, Human
ELISA, IHC, IP, WB
APC Conjugated
100 µl/$1,144
PRNP / PrP / Prion Mouse anti-Human Monoclonal (PE) Antibody
Hamster, Cat, Human
ELISA, IHC, IP, WB
PE Conjugated
100 µl/$1,144
PRNP / PrP / Prion Rabbit anti-Mouse Polyclonal (aa143-159) Antibody
Mouse, Rat
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
PRNP / PrP / Prion Mouse anti-Human Monoclonal Antibody
Mouse, Sheep, Bovine, Hamster, Deer, Elk, Human
ELISA, IHC, WB
Unconjugated
100 µl/$1,056
PRNP / PrP / Prion Mouse anti-Human Monoclonal (C-Terminus) (4H7) Antibody
Bovine, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$440; 100 µg/$468
PRNP / PrP / Prion Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µg/$575
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product results
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