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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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PRKDC / DNA‑PKcs Antibody (phospho‑Thr2638) LS‑C198887
DNA-PKcs antibody LS-C198887 is an unconjugated rabbit polyclonal antibody to DNA-PKcs (PRKDC) from human and mouse. Validated for IF and Peptide-ELISA.
Catalog
Size
Price
LS-C198887-50
50 µl
Unavailable
LS-C198887-100
100 µl
Unavailable

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Product Description

DNA-PKcs antibody LS-C198887 is an unconjugated rabbit polyclonal antibody to DNA-PKcs (PRKDC) from human and mouse. Validated for IF and Peptide-ELISA.
About PRKDC / DNA-PKcs
Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step. P78527 NM_006904 NP_008835.5

PRKDC Antibody, DNA-PK Antibody, DNAPK Antibody, DNPK1 Antibody, HYRC Antibody, HYRC1 Antibody, p350 Antibody, Scid Antibody, XRCC7 Antibody, DNA-PK catalytic subunit Antibody, DNA-PKcs Antibody, p460 Antibody, DNA-dependent protein kinase catalytic subunit Antibody


Specifications

Target
Human PRKDC / DNA-PKcs
Host
Rabbit
Reactivity
Human, Mouse (tested or 100% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • Immunofluorescence (1:100 - 1:500)
  • Peptide Enzyme-Linked Immunosorbent Assay (1:1000)
Immunogen
Synthetic peptide derived from human DNA-PK around the phosphorylation site of Thr2638.
Epitope
pThr2638
Specificity
DNA-PK (Phospho-Thr2638) Antibody detects endogenous levels of DNA-PK only when phosphorylated at threonine2638.
Presentation
PBS, pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol
Storage
Store at -20°C.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Images


Immunofluorescence

Immunofluorescence of HUVEC cells treated with serum 20% 30', using DNA-PK (Phospho-Thr2638) Antibody. The sample on the right was incubated with synthetic peptide.
Immunofluorescence of HUVEC cells treated with serum 20% 30', using DNA-PK (Phospho-Thr2638) Antibody. The sample on the right was incubated with synthetic peptide.

Immunofluorescence

Immunofluorescence of HUVEC cells treated with serum 20% 30', using DNA-PK (Phospho-Thr2638) Antibody. The sample on the right was incubated with synthetic peptide.
Immunofluorescence of HUVEC cells treated with serum 20% 30', using DNA-PK (Phospho-Thr2638) Antibody. The sample on the right was incubated with synthetic peptide.

Immunofluorescence

Immunofluorescence of HUVEC cells treated with serum 20% 30', using DNA-PK (Phospho-Thr2638) Antibody. The sample on the right was incubated with synthetic peptide.
Immunofluorescence of HUVEC cells treated with serum 20% 30', using DNA-PK (Phospho-Thr2638) Antibody. The sample on the right was incubated with synthetic peptide.

Immunofluorescence

Immunofluorescence of HUVEC cells treated with serum 20% 30', using DNA-PK (Phospho-Thr2638) Antibody. The sample on the right was incubated with synthetic peptide.
Immunofluorescence of HUVEC cells treated with serum 20% 30', using DNA-PK (Phospho-Thr2638) Antibody. The sample on the right was incubated with synthetic peptide.


Requested From: 
Date Requested: 6/21/2018

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