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Anti-PRKDC / DNA-PKcs Antibody (phospho-Thr2609) LS-C64814


Wt. Vol. Conc. Price
100 µg 100 µl - $575
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)

Most Popular PRKDC / DNA-PKcs Antibodies

Anti-PRKDC / DNA-PKcs Antibody (phospho-Thr2609) IHC-plus™ LS-B409
Rabbit Polyclonal to Human PRKDC / DNA-PKcs
IHC - Paraffin, Western blot, ELISA
Immunohistochemistry Image
Anti-PRKDC / DNA-PKcs Antibody (clone 42-psc, Azide-free) LS-C88135
Mouse Monoclonal [clone 42-psc] (IgG1,k) to Human PRKDC / DNA-PKcs
IHC - Paraffin, Immunofluorescence, Gel shift
Unconjugated, Azide-free
Immunohistochemistry Image
Anti-PRKDC / DNA-PKcs Antibody (aa4061-4110) IHC-plus™ LS-B6857
Rabbit Polyclonal (IgG) to Human PRKDC / DNA-PKcs
Human, Mouse
IHC - Paraffin, Immunofluorescence, Western blot, ELISA
Immunohistochemistry Image

100% Guaranteed 100% Guaranteed
Rabbit Polyclonal (IgG) to Human PRKDC / DNA-PKcs
Human, Monkey
Western blot


Human PRKDC / DNA-PKcs
Human, Monkey (tested or 100% immunogen sequence identity)
IgG Polyclonal
Immunoaffinity purified


Western blot

Specificity and Use

PRKDC / DNA-PKcs antibody was raised against synthetic peptide: PMFVEpTQASQG, corresponding to amino acids 2604-2614 of Human DNA PKcs (phosphorylated form of human DNA PKcs at the pT2609 residue).
This phospho specific polyclonal antibody reacts with phosphorylated pT2609 of human DNA PKcs. Reactivity with non-phosphorylated human DNA PKcs is minimal by ELISA. This antibody recognizes phospho T2609 DNA PKcs as demonstrated: IPed DNA PKcs (using another DNA PKcs antibody) blotted with the pT2609 antibody shows an inducible signal at the correct height after DNA damage. However, unfortunately the antibody picks up an IR-inducible signal in cells lacking DNA-PKcs (MO59J cells) at the same size as DNA-PKcs. We believe that this is 53BP1 which runs at the same size as DNA-PKcs and is also phosphorylated in an IR-dependent manner. Similar results were seen with another phospho DNA-PKcs antibody indicating that this result is general to antibodies to this phospho site, rather than specific to this antibody. This antibody may be a useful marker for DNA damage. It may also still be useful in the study of phospho DNA PKcs T2609. Species cross-reactivity: Cross-reacts with Human.
Suitable for use in Western Blot.


For research use only.

About PRKDC / DNA-PKcs

P78527 NM_006904 NP_008835.5

PRKDC Antibody, DNA-PK Antibody, DNAPK Antibody, DNPK1 Antibody, HYRC Antibody, HYRC1 Antibody, p350 Antibody, Scid Antibody, XRCC7 Antibody, DNA-PK catalytic subunit Antibody, DNA-PKcs Antibody, p460 Antibody, DNA-dependent protein kinase catalytic subunit Antibody

Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step.

Requested From: United States
Date Requested: 10/21/2016

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