Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Human, Mouse, Rat (tested or 100% immunogen sequence identity)
Specificity and Use
Produced against a chemically synthesized phosphopeptide derived from a region of human PKC I&II that contains threonine 500.
Reactivity: Human PKC I&II. Mouse and rat PKC I&II have not been tested, but are expected to react. Cross-reacts with PKC [pT497] (88% homologous) and partially cross-reacts with PKC [pT514] (63% homologous) and [pT566] (75% homologous), as determined by peptide competition experiments.
Suitable for use in Western blotting applications. For Western blotting applications, we recommend using the antibody at a 1:1000 dilution. Positive control: K562 cells treated with PMA, a phorbol ester.
PRKCB Antibody, PKC beta 2 Antibody, Pkc betaII Antibody, PRKCB2 Antibody, Protein kinase c beta Antibody, Protein kinase c beta 2 Antibody, Protein kinase c beta i Antibody, Protein kinase C beta type Antibody, Protein kinase C, beta Antibody, Protein kinase C, beta 1 Antibody, PRKCB1 Antibody, Pkc betaI Antibody, PKC-beta Antibody, PKCB Antibody, Pkcbeta Antibody, PkcbetaI Antibody, PKC-B Antibody, PkcbetaII Antibody, Protein kinase c beta 1 Antibody, Protein kinase c beta II Antibody
Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation.