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PRKAG1 / AMPK Gamma 1

protein kinase, AMP-activated, gamma 1 non-catalytic subunit

AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive.

Gene Name: protein kinase, AMP-activated, gamma 1 non-catalytic subunit
Family/Subfamily: Protein Kinase Non Catalytic , AMPK/SNF1
Synonyms: PRKAG1, AMPK gamma 1, AMPK gamma-1 chain, AMPK subunit gamma-1, AMPKG, AMPK gamma1
Target Sequences: NM_002733 NP_002724.1 P54619

Publications (2)

1
Hypothalamic CaMKK2 contributes to the regulation of energy balance. Anderson KA, Ribar TJ, Lin F, Noeldner PK, Green MF, Muehlbauer MJ, Witters LA, Kemp BE, Means AR. Cell metabolism. 2008 7:377-88. (WB) [PubMed:18460329]
2
Porcine HMGCR Inhibits Porcine Circovirus Type 2 Infection by Directly Interacting with the Viral Proteins. Ouyang T, Niu G, Zhang Y, Liu X, Zhang X, Zhang S, Geng Y, Pang D, Ouyang H, Ren L. Viruses. 2019 June;11:E544. [Full Text Article] [PubMed:31212640] [PMC:PMC6630565] Related Antibodies: LS-C326839.

☰ Filters
Antibodies (41)
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PRKAG1 / AMPK Gamma 1 (55)
Human (43)
Mouse (36)
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rabbit (39)
mouse (2)
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monoclonal mc (2)
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Select
PRKAG1 / AMPK Gamma 1 Rabbit anti-Human Polyclonal (aa265-295) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
Select
PRKAG1 / AMPK Gamma 1 Rabbit anti-Human Polyclonal (aa265-295) (Biotin) Antibody
Mouse, Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
Select
PRKAG1 / AMPK Gamma 1 Rabbit anti-Human Polyclonal (aa265-295) (FITC) Antibody
Mouse, Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
Select
PRKAG1 / AMPK Gamma 1 Rabbit anti-Human Polyclonal (aa265-295) (Azide-free) (HRP) Antibody
Mouse, Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
Select
PRKAG1 / AMPK Gamma 1 Rabbit anti-Human Polyclonal (aa265-295) (APC) Antibody
Mouse, Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
Select
PRKAG1 / AMPK Gamma 1 Rabbit anti-Human Polyclonal (aa265-295) (PE) Antibody
Mouse, Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
PRKAG1 / AMPK Gamma 1 Antibody - IHC of paraffin-embedded cervical cancer tissues using PRKAG1 mouse monoclonal antibody with DAB staining.
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PRKAG1 / AMPK Gamma 1 Mouse anti-Human Monoclonal (aa230-331) (4A1G9) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
100 µl/$459
PRKAG1 / AMPK Gamma 1 Antibody - Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE), at a concentration of 10 ug/ml.
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PRKAG1 / AMPK Gamma 1 Mouse anti-Human Monoclonal (aa230-331) (7H3E9) Antibody
Human
ELISA, Flo, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$460
PRKAG1 / AMPK Gamma 1 Antibody - Immunohistochemistry of paraffin-embedded human testis tissue at dilution of 1:100
Select
PRKAG1 / AMPK Gamma 1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$294; 100 µg/$360
PRKAG1 / AMPK Gamma 1 Antibody - Immunohistochemistry of paraffin-embedded human stomach tissue.
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PRKAG1 / AMPK Gamma 1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
Select
PRKAG1 / AMPK Gamma 1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
PRKAG1 / AMPK Gamma 1 Antibody - Staining 293 cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 min at 25°C. The primary antibody was diluted at 1:200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody, diluted at 1/600, was used as secondary antibody.
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PRKAG1 / AMPK Gamma 1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
PRKAG1 / AMPK Gamma 1 Antibody - Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
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PRKAG1 / AMPK Gamma 1 Rabbit anti-Human Polyclonal (aa265-295) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
Select
PRKAG1 / AMPK Gamma 1 Rabbit anti-Human Polyclonal (aa1-30) Antibody
Mouse, Human
ELISA, WB
Unconjugated
200 µl/$734
Select
PRKAG1 / AMPK Gamma 1 Rabbit anti-Human Polyclonal (aa1-30) (Biotin) Antibody
Mouse, Human
ELISA, WB
Biotin Conjugated
200 µl/$952
Select
PRKAG1 / AMPK Gamma 1 Rabbit anti-Human Polyclonal (aa1-30) (FITC) Antibody
Mouse, Human
ELISA, WB
FITC Conjugated
200 µl/$952
Select
PRKAG1 / AMPK Gamma 1 Rabbit anti-Human Polyclonal (aa1-30) (APC) Antibody
Mouse, Human
ELISA, WB
APC Conjugated
200 µl/$952
Select
PRKAG1 / AMPK Gamma 1 Rabbit anti-Human Polyclonal (aa1-30) (PE) Antibody
Mouse, Human
ELISA, WB
PE Conjugated
200 µl/$952
Select
PRKAG1 / AMPK Gamma 1 Rabbit anti-Human Polyclonal (aa1-30) (Azide-free) (HRP) Antibody
Mouse, Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
Select
PRKAG1 / AMPK Gamma 1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
PRKAG1 / AMPK Gamma 1 Antibody - Western blot of AMPKgamma1 antibody
Select
PRKAG1 / AMPK Gamma 1 Rabbit anti-Human Polyclonal (10-90 aa, N-terminal) Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
PRKAG1 / AMPK Gamma 1 Antibody - Western blot analysis of Human fetal liver tissue, using PRKAG1 Polyclonal Antibody at dilution of 1:500.
Select
PRKAG1 / AMPK Gamma 1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
PRKAG1 / AMPK Gamma 1 Antibody - Western blot analysis of extracts from 293 cells, using PRKAG1 antibody.
Select
PRKAG1 / AMPK Gamma 1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µg/$357
PRKAG1 / AMPK Gamma 1 Antibody - Western blot analysis of the lysates from HT-29 cells using PRKAG1 antibody.
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PRKAG1 / AMPK Gamma 1 Rabbit anti-Human Polyclonal (aa26-75) Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
Select
PRKAG1 / AMPK Gamma 1 Rabbit anti-Human Polyclonal (aa36-81) Antibody
Mouse, Rat, Human
WB
Unconjugated
50 µl/$321; 100 µl/$403
Viewing 1-25 of 55 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).