Drosophila PRKAA1 / AMPK Alpha 1

Mouse

Drosophila (tested or 100% immunogen sequence identity)

IgG2a Monoclonal

84.1

Unconjugated

Protein G purified

Unmodified

29 AA peptide within the N-Terminus catalytic domain of Drosophila AMPK alpha.

N-Terminus

Recognizes both the alpha 1 and the alpha 2 isoforms of AMP-activated protein kinase (AMPK). AMPK is a highly conserved heterotrimeric protein kinase found in all eukaryotes. The heterotrimeric complex exists as multiple isoforms and consists of a catalytic alpha subunit, which is stabilized by non-catalytic regulatory beta- and gamma- subunits. AMPK plays a vital role in maintaining cellular energy homeostasis and is activated by rising levels of AMP under conditions of hypoxia, ischemia, exercise, low glucose levels. AMPK may play an important role in the control of type 2 diabetes and metabolic syndromes. Recent studies suggest that AMPK functions as a suppressor of cell proliferation of both malignant and normal cells.

• IHC - Frozen
• Immunofluorescence
• Western blot (1:100 - 1:1000)
• Immunoprecipitation
• ELISA

PBS, 0.09% Sodium Azide

Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: Q13131 NCBI: NM_006251 NP_006242.5