Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal (IgG1) to Human PRG2 / Proteoglycan 2
IHC, Immunofluorescence, ELISA
Human PRG2 / Proteoglycan 2
Human (tested or 100% immunogen sequence identity)
Immunofluorescence (1:100 - 1:200)
Specificity and Use
Reacts specifically from human eosinophil major basic protein from eosinophils among peripheral blood cells. Eosinophil major basic protein is felt to play an important role in eosinophil function and perhaps endothelial injury in hypereosinophilic states
ELISA at 1:800. Indirect immunofluorescence at 1:100-1:200. Optimal working dilutions must be determined by end user.
Store at -20°C. Aliquot to avoid freeze/thaw cycles. Store undiluted.
PRG2 Antibody, BMPG Antibody, Bone marrow proteoglycan Antibody, Bone-marrow proteoglycan Antibody, Eosinophil major basic protein Antibody, MBP1 Antibody, Natural killer cell activator Antibody, Proteoglycan 2 Antibody, Proteoglycan 2 preproprotein Antibody
PRG2 / Proteoglycan 2 is the predominant constituent of the crystalline core of the eosinophil granule. High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plasma protein A (PAPPA), angiotensinogen (AGT), and C3dg. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and in immune hypersensitivity reactions.