PPP1R12A / MYPT1

protein phosphatase 1, regulatory subunit 12A

Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC. Thus, Rho appears to inhibit myosin phosphatase through the action of Rho-kinase. Several transcript variants encoding different isoforms have been found for this gene.

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Products

Antibodies (50)

Proteins (6)

ELISA Kits (2)

Type

Cell-Based (1)

Cell-Based Phosphorylation (1)

Over-Expression Lysate (4)

Primary (50)

Recombinant (2)

Target

PPP1R12A / MYPT1 (58)

Reactivity

Human (52)

Mouse (44)

Rat (37)

Bat (6)

Bovine (3)

Chicken (6)

Chimpanzee (3)

Dog (6)

Gibbon (3)

Guinea pig (5)

Horse (4)

Monkey (5)

Orangutan (3)

Pig (3)

Rabbit (5)

Sheep (2)

Zebrafish (5)

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Application

IHC (27)

IHC-P (8)

WB (46)

ELISA (18)

IF (4)

IP (3)

Peptide-ELISA (7)

Host

rabbit (49)

goat (1)

Product Group

IHCPlus (1)

Isotype

Ig (8)

IgG (27)

Clonality

monoclonal mc (1)

polyclonal pc (49)

Format

96-Well Microplate (2)

Biotin Conjugated (1)

FITC Conjugated (1)

HRP Conjugated (1)

Unconjugated (47)

Epitope

pThr853 (5)

aa860-909 (4)

pThr696 (4)

N-Terminus (3)

590-670 aa (2)

Internal (2)

Ser668 (2)

pSer668 (2)

pThr850 (2)

630-710 aa (1)

Arg690 (1)

Ser507 (1)

aa1-17 (1)

aa1-40 (1)

aa400-450 (1)

aa621-670 (1)

aa661-710 (1)

aa800-850 (1)

p696 (1)

p853 (1)

pSer507 (1)

pThr852 (1)

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Publications

No (57)

Yes (1)

Sample Type

Adherent Cell Cultures (2)

Tag

Myc-DDK (Flag) (6)

Species

Human (4)

Source

293T Cells (2)

HEK 293 Cells (4)

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PPP1R12A / MYPT1 Antibody (aa661-710) LS-C117671

(4.1) Rating

(2) Publication(s)

Antibody:

PPP1R12A / MYPT1 Rabbit anti-Human Polyclonal (aa661-710) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

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PPP1R12A / MYPT1 Antibody (aa800-850) LS-C287730

Antibody:

PPP1R12A / MYPT1 Rabbit anti-Human Polyclonal (aa800-850) Antibody

Reactivity:

Human

Applications:

IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

Select

IHC-plus™ PPP1R12A / MYPT1 Antibody LS-B3836

(4.0) Rating

Antibody:

PPP1R12A / MYPT1 Goat anti-Human Polyclonal Antibody

Reactivity:

Mouse, Dog, Bovine, Rat, Horse, Bat, Human, Monkey

Applications:

IF, IHC, IHC-P, Peptide-ELISA

Format:

Unconjugated

Price:

50 µg/$485

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PPP1R12A / MYPT1 Antibody (phospho-Thr696) LS-C199296

Antibody:

PPP1R12A / MYPT1 Rabbit anti-Human Polyclonal (pThr696) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, IHC-P, Peptide-ELISA

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

PPP1R12A / MYPT1 Antibody (N-Terminus) LS-C153530

Antibody:

PPP1R12A / MYPT1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µg/$440; 100 µg/$480

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PPP1R12A / MYPT1 Antibody (aa621-670) LS-C117672

Antibody:

PPP1R12A / MYPT1 Rabbit anti-Human Polyclonal (aa621-670) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

PPP1R12A / MYPT1 Antibody LS-C746743

Antibody:

PPP1R12A / MYPT1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IP, WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

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PPP1R12A / MYPT1 Antibody (phospho-Thr850) LS-C130965

Antibody:

PPP1R12A / MYPT1 Rabbit anti-Human Monoclonal (pThr850) Antibody

Reactivity:

Chicken, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$720

Select

Mouse/Human/Rat Phospho-PPP1R12A / MYPT1 (Thr853) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1191

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

Select

PPP1R12A / MYPT1 Antibody (phospho-Thr853) LS-C199297

Antibody:

PPP1R12A / MYPT1 Rabbit anti-Human Polyclonal (pThr853) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

PPP1R12A / MYPT1 Antibody (phospho-Thr853) LS-C801515

Antibody:

PPP1R12A / MYPT1 Rabbit anti-Human Polyclonal (pThr853) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

Select

PPP1R12A / MYPT1 Antibody LS-C801516

Antibody:

PPP1R12A / MYPT1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

Select

PPP1R12A / MYPT1 Antibody (phospho-Thr853) LS-C417263

Antibody:

PPP1R12A / MYPT1 Rabbit anti-Human Polyclonal (pThr853) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

50 µg/$305; 100 µg/$357

Select

PPP1R12A / MYPT1 Antibody (phospho-Thr850) LS-C91059

Antibody:

PPP1R12A / MYPT1 Rabbit anti-Human Polyclonal (pThr850) Antibody

Reactivity:

Chicken, Zebrafish, Horse, Rat, Rabbit, Mouse, Dog, Human, Monkey

Applications:

WB

Format:

Unconjugated

Price:

200 µg/$1,054

Select

PPP1R12A / MYPT1 Antibody (phospho-Ser668) LS-C763623

Antibody:

PPP1R12A / MYPT1 Rabbit anti-Human Polyclonal (pSer668) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

50 µl/$434

Select

Human PPP1R12A / MYPT1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67955

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

115.1 kDa

Price:

20 µg/$1,107

Select

Human PPP1R12A / MYPT1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81076

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

117 kDa

Price:

20 µg/$215

Select

Mouse/Human/Rat PPP1R12A / MYPT1 (Cell-Based ELISA) ELISA Kit - LS-F2177

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$618

Select

PPP1R12A / MYPT1 Antibody (aa1-40) LS-C407949

Antibody:

PPP1R12A / MYPT1 Rabbit anti-Human Polyclonal (aa1-40) Antibody

Reactivity:

Mouse, Dog, Guinea pig, Sheep, Bovine, Rat, Pig, Horse, Bat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

Select

PPP1R12A / MYPT1 Antibody (630-710 aa) LS-C381716

Antibody:

PPP1R12A / MYPT1 Rabbit anti-Human Polyclonal (630-710 aa) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

PPP1R12A / MYPT1 Antibody (phospho-Thr696) LS-C821875

Antibody:

PPP1R12A / MYPT1 Rabbit anti-Human Polyclonal (pThr696) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC

Format:

Unconjugated

Price:

100 µg/$357

Select

PPP1R12A / MYPT1 Antibody (590-670 aa) LS-C384731

Antibody:

PPP1R12A / MYPT1 Rabbit anti-Human Polyclonal (590-670 aa) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

PPP1R12A / MYPT1 Antibody LS-C667027

Antibody:

PPP1R12A / MYPT1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$331

Select

PPP1R12A / MYPT1 Antibody (p696) LS-C827618

Antibody:

PPP1R12A / MYPT1 Rabbit anti-Human Polyclonal (p696) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

PPP1R12A / MYPT1 Antibody (590-670 aa) LS-C381250

Antibody:

PPP1R12A / MYPT1 Rabbit anti-Human Polyclonal (590-670 aa) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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