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PPM1F

protein phosphatase, Mg2+/Mn2+ dependent, 1F

PPM1F is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. The overexpression of this phosphatase or CAMK2G has been shown to mediate caspase-dependent apoptosis. An alternatively spliced transcript variant has been identified, but its full-length nature has not been determined.

Gene Name: protein phosphatase, Mg2+/Mn2+ dependent, 1F
Family/Subfamily: Protein Phosphatase , PP2C
Synonyms: PPM1F, CAMKP, CaMKPase, FEM-2, PP2C phosphatase, Protein fem-2 homolog, Protein phosphatase 1F, POPX2, CaM-kinase phosphatase, HFEM-2, KIAA0015, Partner of PIX 2
Target Sequences: NM_014634 NP_055449.1 P49593

☰ Filters
Antibodies (23)
Proteins (6)
Over-Expression Lysate (2)
Primary (23)
Recombinant (4)
PPM1F (29)
Human (23)
IHC (16)
IHC-P (9)
WB (20)
ELISA (16)
IF (1)
rabbit (22)
mouse (1)
Product Group
IHCPlus (1)
IgG (19)
IgG1,k (1)
monoclonal mc (1)
polyclonal pc (22)
AT6D11 (1)
APC Conjugated (2)
Azide-free (2)
Biotin Conjugated (3)
FITC Conjugated (3)
HRP Conjugated (3)
PE Conjugated (2)
Unconjugated (10)
aa11-40 (7)
aa275-303 (7)
aa409-439 (1)
No (29)
GST (1)
GST, N-terminus (1)
His (1)
Myc-DDK (Flag) (3)
Human (5)
293T Cells (1)
E. coli (1)
HEK 293 Cells (2)
Wheat Germ Extract (2)
Purified (2)
PPM1F Antibody - Immunohistochemistry image at a dilution of 1:100 and staining in paraffin-embedded human melanoma cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0) . Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4 °C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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PPM1F Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$294; 100 µg/$360
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PPM1F Rabbit anti-Human Polyclonal (HRP) Antibody
Human
HRP Conjugated
50 µg/$294; 100 µg/$360
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PPM1F Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
Biotin Conjugated
50 µg/$294; 100 µg/$360
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PPM1F Rabbit anti-Human Polyclonal (FITC) Antibody
Human
FITC Conjugated
50 µg/$294; 100 µg/$360
PPM1F Antibody - Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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PPM1F Rabbit anti-Human Polyclonal (aa275-303) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
200 µl/$665
PPM1F Antibody - Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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PPM1F Rabbit anti-Human Polyclonal (aa275-303) (Biotin) Antibody
Human
ELISA, IHC, IHC-P, WB
Biotin Conjugated
200 µl/$952
PPM1F Antibody - Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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PPM1F Rabbit anti-Human Polyclonal (aa275-303) (FITC) Antibody
Human
ELISA, IHC, IHC-P, WB
FITC Conjugated
200 µl/$952
PPM1F Antibody - Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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PPM1F Rabbit anti-Human Polyclonal (aa275-303) (APC) Antibody
Human
ELISA, IHC, IHC-P, WB
APC Conjugated
200 µl/$952
PPM1F Antibody - Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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PPM1F Rabbit anti-Human Polyclonal (aa275-303) (PE) Antibody
Human
ELISA, IHC, IHC-P, WB
PE Conjugated
200 µl/$952
PPM1F Antibody - Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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PPM1F Rabbit anti-Human Polyclonal (aa275-303) (Azide-free) (HRP) Antibody
Human
ELISA, IHC, IHC-P, WB
HRP Conjugated, Azide-free
200 µl/$952
PPM1F Antibody - Immunohistochemistry of paraffin-embedded Human thyroid cancer using PPM1F Polyclonal Antibody at dilution of 1:40.
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PPM1F Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
PPM1F Antibody - Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
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PPM1F Rabbit anti-Human Polyclonal (aa11-40) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
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PPM1F Rabbit anti-Human Polyclonal (aa11-40) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
Select
PPM1F Rabbit anti-Human Polyclonal (aa11-40) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
Select
PPM1F Rabbit anti-Human Polyclonal (aa11-40) (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
Select
PPM1F Rabbit anti-Human Polyclonal (aa11-40) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
Select
PPM1F Rabbit anti-Human Polyclonal (aa11-40) (PE) Antibody
Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
Select
PPM1F Rabbit anti-Human Polyclonal (aa11-40) (Azide-free) (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
PPM1F Antibody - Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Select
PPM1F Rabbit anti-Human Polyclonal (aa409-439) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
PPM1F Antibody - Western Blot: The lysate of Jurkat (40 ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human PPM1F antibody (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.
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PPM1F Mouse anti-Human Monoclonal (AT6D11) Antibody
Human
ELISA, WB
Unconjugated
50 µl/$303; 100 µl/$365
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PPM1F Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$341
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PPM1F Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
PPM1F Antibody - PPM1F Antibody western blot of MCF-7 cell line lysates (35 ug/lane). The PPM1F antibody detected the PPM1F protein (arrow).
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PPM1F Rabbit anti-Human Polyclonal (aa275-303) Antibody
Human
WB
Unconjugated
400 µl/$393
PPM1F Protein - Purified recombinant protein PPM1F was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
49.7 kDa
20 µg/$1,107
PPM1F Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
Viewing 1-25 of 29 product results



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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).