Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
PPM1A Antibody, PP2Calpha Antibody, Protein phosphatase 1A Antibody, Protein phosphatase 2C alpha Antibody, Protein phosphatase IA Antibody, PP2CA Antibody, PPPM1A Antibody, PP2C-ALPHA Antibody
PPM1A / PP2CA is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses.
Formalin-fixed and paraffin-embedded human colon carcinoma tissue reacted with PPM1A antibody (C-term) LS-C101066, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma; HC = hepatocarcinoma.
Western blot of anti-PPM1A Pab LS-C101066 in mouse kidney tissue lysate (35 ug/lane). PPM1A(arrow) was detected using the purified Pab (1:60 dilution).