POT1

protection of telomeres 1

Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. Is a component of the double-stranded telomeric DNA-binding TRF1 complex which is involved in the regulation of telomere length by cis-inhibition of telomerase. Also acts as a single-stranded telomeric DNA-binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Binds to two or more telomeric single-stranded 5'-TTAGGG-3' repeats (G-strand) and with high specificity to a minimal telomeric single-stranded 5'-TAGGGTTAG-3' sequence. Binds telomeric single-stranded sequences internally or at proximity of a 3'-end. Its activity is TERT dependent but it does not increase TERT activity by itself. In contrast, the ACD-POT1 heterodimer enhances telomere elongation by increasing telomerase processivity.

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Antibodies (30)

Proteins (4)

ELISA Kits (2)

Type

Over-Expression Lysate (2)

Primary (30)

Recombinant (2)

Sandwich (2)

Target

POT1 (36)

Reactivity

Human (32)

Mouse (5)

Rat (2)

Bovine (3)

Chimpanzee (3)

Dog (3)

Gibbon (6)

Guinea pig (6)

Horse (3)

Monkey (2)

Orangutan (6)

Pig (3)

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Application

IHC (4)

IHC-P (1)

WB (26)

ELISA (6)

IF (2)

Peptide-ELISA (2)

Host

rabbit (29)

rabbit-new zealand white (1)

Isotype

IgG (9)

Clonality

polyclonal pc (30)

Format

96-Well Microplate (1)

96-Well Strip Plate (1)

Biotin Conjugated (5)

DY488 Conjugated (1)

DY550 Conjugated (1)

DY650 Conjugated (1)

FITC Conjugated (4)

HRP Conjugated (4)

Unconjugated (14)

Epitope

aa251-300 (8)

Internal (7)

C-Terminus (4)

aa195-234 (1)

aa200-300 (1)

aa247-296 (1)

aa383-433 (1)

Publications

No (36)

Sample Type

Cell Lysates (1)

Plasma (1)

Serum (1)

Tissue Homogenates (1)

Tag

GST, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (3)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

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POT1 Antibody (aa251-300) LS-C116785

Antibody:

POT1 Rabbit anti-Human Polyclonal (aa251-300) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

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POT1 Antibody (aa251-300, HRP) LS-C464841

Antibody:

POT1 Rabbit anti-Human Polyclonal (aa251-300) (HRP) Antibody

Reactivity:

Mouse, Guinea pig, Bovine, Human, Chimpanzee, Orangutan, Gibbon

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$469

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POT1 Antibody (aa251-300, Biotin) LS-C464839

Antibody:

POT1 Rabbit anti-Human Polyclonal (aa251-300) (Biotin) Antibody

Reactivity:

Mouse, Guinea pig, Bovine, Human, Chimpanzee, Orangutan, Gibbon

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$469

Select

POT1 Antibody (aa251-300, FITC) LS-C464840

Antibody:

POT1 Rabbit anti-Human Polyclonal (aa251-300) (FITC) Antibody

Reactivity:

Mouse, Guinea pig, Bovine, Human, Chimpanzee, Orangutan, Gibbon

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

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POT1 Antibody (aa200-300) LS-C2849

Antibody:

POT1 Rabbit anti-Human Polyclonal (aa200-300) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

0.1 ml/$386

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POT1 Antibody (Internal, Biotin) LS-C142239

Antibody:

POT1 Rabbit anti-Human Polyclonal (Internal) (Biotin) Antibody

Reactivity:

Human

Applications:

WB

Format:

Biotin Conjugated

Price:

0.1 ml/$416

Select

POT1 Antibody (Internal, DY650) LS-C142240

Antibody:

POT1 Rabbit anti-Human Polyclonal (Internal) (DY650) Antibody

Reactivity:

Human

Applications:

WB

Format:

DY650 Conjugated

Price:

0.1 ml/$416

Select

POT1 Antibody (Internal, DY488) LS-C142241

Antibody:

POT1 Rabbit anti-Human Polyclonal (Internal) (DY488) Antibody

Reactivity:

Human

Applications:

WB

Format:

DY488 Conjugated

Price:

0.1 ml/$416

Select

POT1 Antibody (Internal, DY550) LS-C142243

Antibody:

POT1 Rabbit anti-Human Polyclonal (Internal) (DY550) Antibody

Reactivity:

Human

Applications:

WB

Format:

DY550 Conjugated

Price:

0.1 ml/$416

• Unconjugated
• Biotin
• DY650
• DY488
• DY550

• Unconjugated
• Biotin
• DY650
• More...
  • DY488
  • DY550

Select

POT1 Antibody LS-C679099

Antibody:

POT1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

Select

POT1 Antibody (HRP) LS-C679102

Antibody:

POT1 Rabbit anti-Human Polyclonal (HRP) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

HRP Conjugated

Price:

50 µg/$294; 100 µg/$360

Select

POT1 Antibody (Biotin) LS-C679101

Antibody:

POT1 Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Biotin Conjugated

Price:

50 µg/$294; 100 µg/$360

Select

POT1 Antibody (FITC) LS-C679100

Antibody:

POT1 Rabbit anti-Human Polyclonal (FITC) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

FITC Conjugated

Price:

50 µg/$294; 100 µg/$360

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

POT1 Antibody LS-C755285

Antibody:

POT1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µg/$341

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POT1 Antibody LS-C331495

Antibody:

POT1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

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POT1 Antibody (aa383-433) LS-C829531

Antibody:

POT1 Rabbit-New Zealand White anti-Human Polyclonal (aa383-433) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

100 µl/$393

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POT1 Antibody (Internal) LS-C385596

Antibody:

POT1 Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Human, Monkey

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

POT1 Antibody (aa247-296) LS-C199973

Antibody:

POT1 Rabbit anti-Human Polyclonal (aa247-296) Antibody

Reactivity:

Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

POT1 Antibody LS-C807189

Antibody:

POT1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

Select

POT1 Antibody (Internal) LS-C92035

Antibody:

POT1 Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$649

Select

POT1 Antibody (aa251-300) LS-C116786

Antibody:

POT1 Rabbit anti-Human Polyclonal (aa251-300) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

Select

POT1 Antibody (aa251-300, FITC) LS-C464844

Antibody:

POT1 Rabbit anti-Human Polyclonal (aa251-300) (FITC) Antibody

Reactivity:

Pig, Horse, Dog, Guinea pig, Human, Orangutan, Gibbon

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• FITC

• Unconjugated
• FITC

Select

POT1 Antibody (C-Terminus) LS-C345698

Antibody:

POT1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

Select

POT1 Antibody (aa195-234) LS-C407992

Antibody:

POT1 Rabbit anti-Human Polyclonal (aa195-234) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

Select

POT1 Antibody (Internal) LS-C353386

Antibody:

POT1 Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Human, Monkey

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$299

Viewing 1-25 of 36 product results

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