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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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PMS2 Antibody (aa461‑510) LS‑C119589
PMS2 antibody LS-C119589 is an unconjugated rabbit polyclonal antibody to human PMS2. Validated for Peptide-ELISA and WB.
Catalog
Size
Price
LS-C119589-50
50 µl
Unavailable
LS-C119589-100
100 µl
Unavailable

Popular PMS2 Products

Anti-PMS2 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1980 concentration 5 ug/ml.
Species: Human
Applications: IHC, IHC - Paraffin, Western blot
Anti-PMS2 Antibody - Western Blot. Western blot analysis is shown using Protein A Purified Mouse Monoclonal Anti-PMS2 antibody to detect human PMS2 protein present in H157 cell lysates. Approximately 5,10 and 30 ug of cell lysate was loaded on a 4-12% NuPage SDS-PAGE gel using MES buffer. The blot was incubated with a 1:1000 dilution of the antibody at room temperature followed by washing. A 1:20000 dilution of HRP conjugated Gt-anti-Mouse IgG preceded color development using Pierce Chemicals SuperSignal substrate. Comparison to a molecular weight marker (not shown) indicates a single band of ~96.0 kD corresponding to the expected molecular weight for human PMS2 protein. Other detection systems will yield similar results. Personal communication Morphotek Inc.
Species: Human, Mouse, Rat, Hamster
Applications: Western blot, ELISA
Anti-PMS2 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5688 dilution 1:100.
Species: Human
Applications: IHC, IHC - Paraffin, Peptide Enzyme-Linked Immunosorbent Assay
Immunofluorescence analysis of U20S cells.
Species: Human, Mouse, Rat
Applications: Immunofluorescence, Western blot
Western blot of PMS2 antibody
Species: Human
Applications: IHC, Immunofluorescence, Western blot, ELISA

Product Description

PMS2 antibody LS-C119589 is an unconjugated rabbit polyclonal antibody to human PMS2. Validated for Peptide-ELISA and WB.
About PMS2
Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MLH1 to form MutL alpha. DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. P54278 NM_000535 NP_000526.1

PMS2 Antibody, HNPCC4 Antibody, H_DJ0042M02.9 Antibody, PMS2CL Antibody, PMSL2 Antibody, PMS1 protein homolog 2 Antibody


Specifications

Target
Human PMS2
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • Western blot (1:500 - 1:1000)
  • Peptide Enzyme-Linked Immunosorbent Assay (1:10000)
Immunogen
PMS2 antibody was raised against synthetic peptide from human PMS2 (aa461-510).
Epitope
aa461-510
Specificity
PMS2 Antibody detects endogenous levels of total PMS2 protein.
Presentation
PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol
Storage
Store at -20°C for up to 1 year.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Customer Reviews (0)


Images


Western blot

Western blot of extracts from HeLa cells, using PMS2 Antibody. The lane on the right is treated with the synthesized peptide.
Western blot of extracts from HeLa cells, using PMS2 Antibody. The lane on the right is treated with the synthesized peptide.

Western blot

Western blot of extracts from HeLa cells, using PMS2 Antibody. The lane on the right is treated with the synthesized peptide.
Western blot of extracts from HeLa cells, using PMS2 Antibody. The lane on the right is treated with the synthesized peptide.

Western blot

Western blot of extracts from HeLa cells, using PMS2 Antibody. The lane on the right is treated with the synthesized peptide.
Western blot of extracts from HeLa cells, using PMS2 Antibody. The lane on the right is treated with the synthesized peptide.

Western blot

Western blot of extracts from HeLa cells, using PMS2 Antibody. The lane on the right is treated with the synthesized peptide.
Western blot of extracts from HeLa cells, using PMS2 Antibody. The lane on the right is treated with the synthesized peptide.


Requested From: 
Date Requested: 6/23/2018

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