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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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PML Antibody LS‑C126143
Antibody
PML antibody LS-C126143 is an unconjugated mouse monoclonal antibody to human PML. Validated for WB.
Catalog
Size
Price
LS-C126143-500
500 µg
Unavailable

Popular PML Products

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Species: Human
Applications: IHC, IHC - Paraffin, Immunofluorescence, Western blot, Flow Cytometry
Anti-PML antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3501 concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Species: Human, Mouse, Rat, Bovine, Guinea pig, Horse
Applications: IHC, IHC - Paraffin, Western blot
Immunocytochemistry Image
Species: Mouse
Applications: ICC, Western blot
Western blot of recombinant PML.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Species: Human
Applications: IHC, Western blot
Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
Species: Human, Mouse
Applications: IHC, IHC - Paraffin, Immunofluorescence, Western blot

Product Description

PML antibody LS-C126143 is an unconjugated mouse monoclonal antibody to human PML. Validated for WB.
About PML
Functions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense mechanisms. Acts as the scaffold of PML-NBs allowing other proteins to shuttle in and out, a process which is regulated by SUMO-mediated modifications and interactions. P29590 NM_002675 NP_002666.1

PML Antibody, PP8675 Antibody, Promyelocytic leukemia Antibody, Protein PML Antibody, TRIM19 Antibody, Promyelocytic leukemia protein Antibody, RING finger protein 71 Antibody, MYL Antibody, RNF71 Antibody


Specifications

Target
Human PML
Host
Mouse
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG1,k Monoclonal
Conjugations
Unconjugated
Purification
Purified
Modifications
Unmodified
Applications
  • Western blot (1:2000)
Immunogen
PML antibody was raised against recombinant partial human PML.
Specificity
Recognizes human normal PML proteins of lower molecular weight, and also recognizes the high molecular weight PML/RARa chimeric protein in promyelocytic leukemia patients.
Usage
Suitable for use in Western blot: 1:2000 to differentiate normal PML and chimeric PML/RARa molecules based on their molecular weight.
Presentation
Lyophilized from 0.01 M PBS, pH 7.4
Reconstitution
Sterile 40-50% glycerol, distilled water.
Storage
Lyophilized powder may be stored at -20°C. Stable for 1 year at -20°C. Reconstituted product is stable for 1 year at -20°C Aliquot and store at -20°C.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Requested From: 
Date Requested: 6/20/2018

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