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PMAIP1 / NOXA

phorbol-12-myristate-13-acetate-induced protein 1

Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 By similarity. Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1.

Gene Name: phorbol-12-myristate-13-acetate-induced protein 1
Family/Subfamily: Apoptosis , not assigned-Other
Synonyms: PMAIP1, NOXA, PMA-induced protein 1, Protein Noxa, APR
Target Sequences: NM_021127 NP_066950.1 Q13794

Publications (1)

1
Unique characteristics of radiation-induced apoptosis in the postnatally developing small intestine and colon of mice. Miyoshi-Imamura T, Kakinuma S, Kaminishi M, Okamoto M, Takabatake T, Nishimura Y, Imaoka T, Nishimura M, Murakami-Murofushi K, Shimada Y. Radiation research. 2010 173:310-8. (IHC-P; Mouse) [PubMed:20199216] Related Antibodies: LS-B184.

☰ Filters
Antibodies (27)
ELISA Kits (6)
Proteins (6)
Custom (3)
Over-Expression Lysate (2)
Primary (27)
Recombinant (4)
Sandwich (3)
PMAIP1 / NOXA (39)
Human (25)
Mouse (14)
Rat (11)
Dog (1)
Monkey (1)
IHC (5)
IHC-P (5)
WB (22)
ELISA (8)
ICC (2)
IF (3)
Peptide-ELISA (2)
rabbit (17)
mouse (5)
goat (2)
rat (3)
Product Group
IHCPlus (3)
IgG (15)
IgG1 (2)
IgG1,k (3)
IgG2b,k (3)
monoclonal mc (8)
polyclonal pc (19)
114C307.1 (4)
69N15C9 (2)
ABM16G6 (1)
96-Well Strip Plate (6)
Azide-free (2)
Biotin Conjugated (3)
FITC Conjugated (2)
HRP Conjugated (2)
PE Conjugated (1)
Unconjugated (19)
aa1-103 (2)
N-Terminus (1)
aa1-16 (1)
aa27-41 (1)
aa51-66 (1)
aa75-90 (1)
No (38)
Yes (1)
Plasma (3)
Serum (3)
Tissue Homogenates (2)
6His, N-terminus (1)
GST (1)
His (1)
Myc-DDK (Flag) (3)
Human (5)
293T Cells (1)
E. coli (2)
HEK 293 Cells (2)
Wheat Germ Extract (1)
Purified (1)
Low endotoxin level (1)
PMAIP1 / NOXA Antibody - Anti-NOXA antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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PMAIP1 / NOXA Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$460
PMAIP1 / NOXA Antibody - Anti-NOXA antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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PMAIP1 / NOXA Rabbit anti-Mouse Polyclonal (aa51-66) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µg/$460
PMAIP1 / NOXA ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
PMAIP1 / NOXA Protein - SDS-PAGE under reducing conditions and visualized by Coomassie blue staining
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E. coli
6His, N-terminus
16 kDa
10 µg/$265; 50 µg/$315; 100 µg/$365
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PMAIP1 / NOXA Mouse anti-Human Monoclonal (114C307.1) Antibody
Human
ELISA, ICC, WB
Unconjugated
100 µg/$813
PMAIP1 / NOXA Antibody - PMAIP1 antibody (0.03 ug/ml) staining of Human Cerebellum lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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PMAIP1 / NOXA Goat anti-Human Polyclonal (aa27-41) Antibody
Human, Monkey
Peptide-ELISA, WB
Unconjugated
100 µg/$503
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PMAIP1 / NOXA Mouse anti-Human Monoclonal (Biotin) (114C307.1) Antibody
Mouse, Human
ELISA
Biotin Conjugated
0.1 ml/$416
PMAIP1 / NOXA ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
PMAIP1 / NOXA Antibody - Western blot detection of Noxa in RL-7 cell (a follicular lymphoma) lysate. A protein of approximate molecular weight of 11 kD is detected using antibody at 2 ug/ml.
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PMAIP1 / NOXA Mouse anti-Human Monoclonal (114C307.1) Antibody
Human
WB
Unconjugated
100 µg/$386
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PMAIP1 / NOXA Mouse anti-Human Monoclonal (Azide-free) (114C307.1) Antibody
Mouse, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated, Azide-free
0.1 mg/$386
PMAIP1 / NOXA Antibody - Immunohistochemistry of paraffin-embedded human heart tissue at dilution of 1:100
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PMAIP1 / NOXA Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
PMAIP1 / NOXA Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
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PMAIP1 / NOXA Rabbit anti-Human Polyclonal Antibody
Human
IHC-P, WB
Unconjugated
50 µl/$460
PMAIP1 / NOXA Protein - Purified recombinant protein PMAIP1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
5.8 kDa
20 µg/$1,107
PMAIP1 / NOXA Protein - 12.5% SDS-PAGE of human PMAIP1 stained with Coomassie Blue
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Wheat Germ Extract
GST
40.7 kDa
2 µg/$439
Select
PMAIP1 / NOXA Rabbit anti-Mouse Polyclonal (N-Terminus) Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
100 µg/$649
Select
PMAIP1 / NOXA Goat anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
0.1 mg/$579
PMAIP1 / NOXA Antibody - Fig-3: Western blot analysis of NOXA. Anti-NOXA antibody was used at 4 µg/ml on HCT-116 lysates.
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PMAIP1 / NOXA Mouse anti-Human Monoclonal (ABM16G6) Antibody
Human
WB
Unconjugated
25 µg/$288; 100 µg/$414
Select
PMAIP1 / NOXA Rabbit anti-Human Polyclonal Antibody
Human
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
Select
PMAIP1 / NOXA Rabbit anti-Mouse Polyclonal (aa1-16) Antibody
Mouse, Rat
WB
Unconjugated
100 µl/$688
Select
PMAIP1 / NOXA Rabbit anti-Mouse Polyclonal (aa75-90) Antibody
Mouse, Rat
WB
Unconjugated
100 µl/$688
PMAIP1 / NOXA Antibody - Western Blot: Noxa Antibody (69N15C9) - Western blot analysis of mouse A) Noxa recombinant protein, B) thymus and C) ovary using Noxa antibody at 1ug/ml, 5 ug/ml and 5 ug/ml, respectively.
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PMAIP1 / NOXA Rat anti-Mouse Monoclonal (aa1-103) (69N15C9) Antibody
Mouse
WB
Unconjugated
0.1 mg/$386
PMAIP1 / NOXA Antibody - Western Blot: Noxa Antibody (69N15C9) [Azide Free] - Analysis of mouse A) Noxa recombinant protein, B) thymus and C) ovary using Noxa antibody at 1 ug/ml, 5 ug/ml and 5 ug/ml, respectively. This image was taken for the unmodified form of this product. Other forms have not been tested.
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PMAIP1 / NOXA Rat anti-Mouse Monoclonal (aa1-103) (Azide-free) (69N15C9) Antibody
Mouse
WB
Unconjugated, Azide-free
0.1 mg/$386
Select
PMAIP1 / NOXA Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
PMAIP1 / NOXA Antibody - Fig-1: Western blot analysis of mNOXA. Anti-mNOXA antibody was tested at 1 µg/ml on T98G lysate.
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PMAIP1 / NOXA Rat anti-Human Monoclonal Antibody
Human
WB
Unconjugated
25 µg/$288; 100 µg/$414
PMAIP1 / NOXA Antibody
Select
PMAIP1 / NOXA Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
50 µl/$286; 100 µl/$321
Viewing 1-25 of 39 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).