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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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PMAIP1 / NOXA Antibody (aa27‑41) LS‑C108110
NOXA antibody LS-C108110 is an unconjugated goat polyclonal antibody to NOXA (PMAIP1) from human and monkey. Validated for Peptide-ELISA and WB.
Catalog
Size
Price
LS-C108110-100
100 µg (0.5 mg/ml)
Unavailable

Popular PMAIP1 / NOXA Products

Antibody
Species: Human
Applications: ICC, Western blot, ELISA
Anti-NOXA antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B121 concentration 10 ug/ml.
Species: Mouse, Human, Rat
Applications: IHC, IHC - Paraffin, Western blot
Anti-NOXA antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B184 concentration 5 ug/ml.
Species: Mouse, Human, Rat
Applications: IHC, IHC - Paraffin, Western blot
Antibody
Species: Human, Mouse
Applications: ELISA

Product Description

NOXA antibody LS-C108110 is an unconjugated goat polyclonal antibody to NOXA (PMAIP1) from human and monkey. Validated for Peptide-ELISA and WB.
About PMAIP1 / NOXA
Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 By similarity. Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1. Q13794 NM_021127 NP_066950.1

PMAIP1 Antibody, NOXA Antibody, PMA-induced protein 1 Antibody, Protein Noxa Antibody, APR Antibody


Specifications

Target
Human PMAIP1 / NOXA
Host
Goat
Reactivity
Human, Monkey (tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • Western blot (0.03 - 0.1 µg/ml)
  • Peptide Enzyme-Linked Immunosorbent Assay
Failed Applications
  • IHC - Paraffin
Immunogen
PMAIP1 / NOXA antibody was raised against synthetic peptide C-TQLRRFGDKLNFRQK from an internal region of human PMAIP1 / NOXA (NP_066950.1). Percent identity by BLAST analysis: Human, Monkey, Marmoset (100%); Panda (93%); Dog (87%); Elephant, Pig (80%).
Blocking Peptide
LS-E26958 - Lyophilized - 100 µg - $145.00
Immunizing peptide used to generate LS-C108110. Useful for pre-absorption and neutralization of the antibody's antigen binding site.
Epitope
aa27-41
Specificity
Human PMAIP1 / NOXA.
Usage
Western Blot: Approx 16kD band observed in Human Brain (Cerebellum) lysates (calculated MW of 6.03kD according to NP_066950.1). The observed molecular weight corresponds to earlier findings with different antibodies from other commercial sources. Recommended concentration: 0.03-0.1 ug/ml.
Presentation
Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
Storage
Store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Images


Western blot

PMAIP1 antibody (0.03 ug/ml) staining of Human Cerebellum lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
PMAIP1 antibody (0.03 ug/ml) staining of Human Cerebellum lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Western blot

PMAIP1 antibody (0.03 ug/ml) staining of Human Cerebellum lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
PMAIP1 antibody (0.03 ug/ml) staining of Human Cerebellum lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Western blot

PMAIP1 antibody (0.03 ug/ml) staining of Human Cerebellum lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
PMAIP1 antibody (0.03 ug/ml) staining of Human Cerebellum lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Western blot

PMAIP1 antibody (0.03 ug/ml) staining of Human Cerebellum lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
PMAIP1 antibody (0.03 ug/ml) staining of Human Cerebellum lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.


Requested From: 
Date Requested: 6/21/2018

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