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Anti-PLN / Phospholamban Antibody (aa2-25) IHC-plus™ LS-B2358

Note: This antibody replaces LS-C26050


Wt. Vol. Conc. Price
- 50 µl 1 mg/ml $450
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)

Most Popular PLN / Phospholamban Antibodies

Anti-PLN / Phospholamban Antibody (aa2-25) IHC-plus™ LS-B2358
Mouse Monoclonal (IgG2a) to Dog PLN / Phospholamban
Dog, Human, Bovine, Pig
IHC - Paraffin, ICC, Western blot, Immunoprecipitation
Immunohistochemistry Image
Anti-PLN / Phospholamban Antibody (aa3-14) IHC-plus™ LS-B8337
Goat Polyclonal to Human PLN / Phospholamban
Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Horse, Pig, Rabbit
IHC - Paraffin, Western blot, ELISA
Immunohistochemistry Image
Anti-PLN / Phospholamban Antibody (phospho-Thr17, Biotin) LS-C266487
Rabbit Polyclonal (IgG) to Human PLN / Phospholamban
ELISA, Dot Blot
Biotin Conjugated

100% Guaranteed 100% Guaranteed
Mouse Monoclonal (IgG2a) to Dog PLN / Phospholamban
Dog, Human, Bovine, Pig
IHC - Paraffin, ICC, Western blot, Immunoprecipitation


Dog PLN / Phospholamban
Dog, Human, Bovine, Pig (tested or 100% immunogen sequence identity)
Monkey, Mouse, Rat, Bat, Horse, Rabbit (at least 90% immunogen sequence identity)
IgG2a Monoclonal
Protein A purified


  • IHC - Paraffin (5 µg/ml)
  • ICC
  • Western blot
  • Immunoprecipitation

Specificity and Use

PLN / Phospholamban antibody was raised against synthetic peptide corresponding to aa 2-25 (D2KVQYLTRSAIRRASTIEMPQQAR25) of dog PLB (phospholamban). Percent identity by BLAST analysis: Bovine, Dog, Pig (100%); Human, Monkey, Marmoset, Mouse, Rat, Panda, Bat, Horse, Rabbit, Opossum (96%); Gorilla, Gibbon (92%); Elephant (88%).
Recognizes canine PLB. Recognizes an epitope between aa 9-17 of canine PLB. Detects bands of ~25kD (non-reducing conditions; representing the pentameric form of PLB) and ~5kD (reducing conditions; representing the monomeric form of PLB) by Western Blot. Species cross-reactivity: human, mouse, rat, rabbit chicken, sheep, porcine and guinea pig.
Immunohistochemistry: LS-B2358 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-B2358 was determined to be 5 ug/ml. Western Blot: 2 ug/ml Detects bands of ~25kD (non-reducing conditions; representing the pentameric form of PLB) and ~5kD (reducing conditions; representing the monomeric form of PLB). Function: Increases the calcium uptake in ventricular SR vesicles.


PBS, 0.05% sodium azide.
Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
For research use only.

About PLN / Phospholamban

P26678 NM_002667 NP_002658.1

PLN Antibody, CMD1P Antibody, CMH18 Antibody, PLB Antibody, Cardiac phospholamban Antibody, Phospholamban Antibody

Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca2+. Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN.


Anti-PLN / Phospholamban antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2358 concentration 5 ug/ml.

Requested From: United States
Date Requested: 10/27/2016

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