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PLG / Plasmin / Plasminogen

plasminogen

Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells.

Gene Name: plasminogen
Family/Subfamily: Protease , Serine S1
Synonyms: PLG, Plasmin, Plasminogen
Target Sequences: NM_000301 NP_000292.1 P00747

Publications (5)

1
Borrelia burgdorferi infection-associated surface proteins ErpP, ErpA, and ErpC bind human plasminogen. Brissette CA, Haupt K, Barthel D, Cooley AE, Bowman A, Skerka C, Wallich R, Zipfel PF, Kraiczy P, Stevenson B. Infection and immunity. 2009 77:300-6. [PubMed:19001079] [PMC:PMC2612283]
2
Roles for phagocytic cells and complement in controlling relapsing fever infection. Woodman ME, Cooley AE, Avdiushko R, Bowman A, Botto M, Wooten RM, van Rooijen N, Cohen DA, Stevenson B. Journal of leukocyte biology. 2009 86:727-36. [PubMed:19458267]
3
Functional characterization of Borrelia spielmanii outer surface proteins that interact with distinct members of the human factor H protein family and with plasminogen. Seling A, Siegel C, Fingerle V, Jutras BL, Brissette CA, Skerka C, Wallich R, Zipfel PF, Stevenson B, Kraiczy P. Infection and immunity. 2010 78:39-48. (ELISA; Human) [PubMed:19858303] [PMC:PMC2798189]
4
Leptospiral endostatin-like protein A is a bacterial cell surface receptor for human plasminogen. Verma A, Brissette CA, Bowman AA, Shah ST, Zipfel PF, Stevenson B. Infection and immunity. 2010 78:2053-9. (ELISA; Human) [PubMed:20160016] [PMC:PMC2863546]
5
Borrelia burgdorferi enolase is a surface-exposed plasminogen binding protein. Floden AM, Watt JA, Brissette CA. PloS one. 2011 6:e27502. [PubMed:22087329] [PMC:PMC3210797]
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PLG / Plasmin / Plasminogen (179)
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PLG / Plasmin / Plasminogen Antibody - Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
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PLG / Plasmin / Plasminogen Rabbit anti-Mouse Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, IHC-Fr, IHC-P, WB
Unconjugated
0.05 mg/$515
PLG / Plasmin / Plasminogen Antibody - Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with PLG Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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PLG / Plasmin / Plasminogen Rabbit anti-Human Polyclonal (aa636-665) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
PLG / Plasmin / Plasminogen Antibody - Anti-PLG / Plasmin / Plasminogen antibody IHC staining of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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PLG / Plasmin / Plasminogen Sheep anti-Mouse Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
200 µg/$460
PLG / Plasmin / Plasminogen ELISA Kit
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Sandwich
96-Well Microplate
Human
156 - 10000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$795
PLG / Plasmin / Plasminogen ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
15.63 - 1000 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$856
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E. coli
His
10 µg/$239; 50 µg/$283; 100 µg/$326; 200 µg/$362; 1 mg/$1,065; 500 µg/$722; 5 mg/$1,858; 2 mg/$1,200
PLG / Plasmin / Plasminogen ELISA Kit
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Sandwich
96-Well Microplate
Human
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$771
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PLG / Plasmin / Plasminogen Rabbit anti-Mouse Polyclonal Antibody
Mouse, Rat
ELISA, IHC, IHC-Fr, WB
Unconjugated
100 µl/$400; 1 ml/$527; 10 ml/$3,577
PLG / Plasmin / Plasminogen ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
1 - 500 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Media, Plasma, Serum, Tissue Extracts, Urine
1 Plate/$687
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PLG / Plasmin / Plasminogen Rabbit anti-Rat Polyclonal Antibody
Rat
ELISA, IHC, IHC-Fr, WB
Unconjugated
100 µg/$695; 1 mg/$5,388
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PLG / Plasmin / Plasminogen Mouse anti-Human Monoclonal (11B5-B2) Antibody
Human
ELISA, WB
Unconjugated
1 mg/$828
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PLG / Plasmin / Plasminogen Sheep anti-Mouse Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
1 mg/$463
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PLG / Plasmin / Plasminogen Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
10 mg/$335
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PLG / Plasmin / Plasminogen Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
1 mg/$520
PLG / Plasmin / Plasminogen Antibody - IHC analysis of Angiostatin K1-3 using anti-Angiostatin K1-3 antibody. Angiostatin K1-3 was detected in paraffin-embedded section of human mammary cancer tissues. Heat mediated antigen retrieval was performed in citrate buffer (pH6, epitope retrieval solution) for 20 mins. The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 1µg/ml rabbit anti-Angiostatin K1-3 Antibody overnight at 4°C. Biotinylated goat anti-rabbit IgG was used as secondary antibody and incubated for 30 minutes at 37°C. The tissue section was developed using Strepavidin-Biotin-Complex (SABC) with DAB as the chromogen.
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PLG / Plasmin / Plasminogen Rabbit anti-Human Polyclonal (aa103-352) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
PLG / Plasmin / Plasminogen ELISA Kit
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Sandwich
96-Well Strip Plate
Monkey
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$728
PLG / Plasmin / Plasminogen ELISA Kit
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Competitive EIA
96-Well Strip Plate
Rabbit
62.5 - 4000 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$870
PLG / Plasmin / Plasminogen Protein
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E. coli
None
Biologically active
29.7 kDa
10 µg/$282; 100 µg/$514; 500 µg/$1,098
PLG / Plasmin / Plasminogen Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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PLG / Plasmin / Plasminogen Rabbit anti-Human Polyclonal (aa611-660) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
PLG / Plasmin / Plasminogen Antibody - Staining HeLa cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 min at 25°C. The primary antibody was diluted at 1:200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody.
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PLG / Plasmin / Plasminogen Rabbit anti-Human Polyclonal Antibody
Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
PLG / Plasmin / Plasminogen Antibody - Goat anti Plasminogen antibody was used to detect Plasminogen under reducing (R) and non-reducing (NR) conditions. Reduced samples of purified target proteins contained 4% BME and were boiled for 5 minutes. Samples of ~1ug of protein per lane were run by SDS-PAGE. Protein was transferred to nitrocellulose and probed with 1:3000 dilution of primary antibody. Detection shown was using Dylight 649 conjugated Donkey anti goat. Images were collected using the BioRad VersaDoc System.
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PLG / Plasmin / Plasminogen Goat anti-Human Polyclonal (Lyophilized) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated, Lyophilized
100 µg/$552
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PLG / Plasmin / Plasminogen Rabbit anti-Chicken Polyclonal Antibody
Chicken
Unconjugated
100 µg/$395; 1 mg/$518; 10 mg/$3,275
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PLG / Plasmin / Plasminogen Goat anti-Human Polyclonal Antibody
Human
ELISA, Flo, ID, IHC, IP, WB
Unconjugated
1 mg/$364
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PLG / Plasmin / Plasminogen Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, IF, IHC, WB
Biotin Conjugated
1 ml/$438
PLG / Plasmin / Plasminogen ELISA Kit
Select
Sandwich
96-Well Strip Plate
Guinea pig
15.625 - 1000 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$728
Viewing 1-25 of 179 product results



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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).