Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone 4D2] (IgG2b) to Human PLG / Plasmin / Plasminogen
Human PLG / Plasmin / Plasminogen
Human (tested or 100% immunogen sequence identity)
IgG2b Monoclonal [4D2]
Ion exchange chromatography
Specificity and Use
PLG / Plasmin / Plasminogen antibody was raised against purified human plasminogen.
human plasminogen. MAbs 9D8, 8E7 and 3C2 react with human plasminogen and plasmin molecules. MAbs 5H3 and 8F11 react with plasminogen, plasmin and angiostatin. No cross-reactivity with other human serum proteins
Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis.