Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone U-6] (IgG1) to Human PLAU / Urokinase / uPA
IHC - Frozen, Western blot, ELISA
Human PLAU / Urokinase / uPA
Human (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [U-6]
Protein A purified
IHC - Frozen
Specificity and Use
Native human uPA.
Recognizes the A-chain of human uPA. Binds single and two-chain uPA, uPA/PAI-1 complex and uPA/uPAR complex. A reaction is seen with the amino terminal fragment (ATF) but not with LMW uPA. Reacts with reduced and non-reduced uPA in Western blotting. It in
Suitable for use in ELISA, Western blot and Immunohistochemistry. Immunohistochemistry: frozen sections.
PBS, pH 7.4, 15 mM sodium azide
Long term: Add glycerol (40-50%) -20°C; Short term: +4°C.
PLAU / Urokinase / uPA is a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen.