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PLAU / Urokinase / uPA

plasminogen activator, urokinase

PLAU / Urokinase / uPA is a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene Name: plasminogen activator, urokinase
Family/Subfamily: Protease , Serine S1
Synonyms: PLAU, BDPLT5, U-PA, U-plasminogen activator, URK, Urokinase, Plasminogen activator, urinary, QPD, UPA
Target Sequences: NM_002658 NP_002649.1 P00749

Publications (1)

1
Preclinical evaluation of [111 In]MICA-401, an activity-based probe for SPECT imaging of in vivo uPA activity. Christel Vangestel, David Thomae, Jeroen Van Soom, Johan Ides, Leonie Wyffels, Patrick Pauwels, Sigrid Stroobants, Pieter Van der Veken, Viktor Magdolen, Jurgen Joossens, Koen Augustyns, Steven Staelens. Contrast media & molecular imaging. 2016 November;11:448-458. [Full Text Article] [PubMed:27558262] Related Antibodies: LS-C150831.

☰ Filters
Antibodies (122)
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PLAU / Urokinase / uPA (178)
Human (88)
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PLAU / Urokinase / uPA Rabbit anti-Mouse Polyclonal Antibody
Mouse, Rat
ELISA, IHC, IHC-Fr, WB
Unconjugated
100 µg/$689; 1 mg/$4,815
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PLAU / Urokinase / uPA Goat anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-Fr, IHC-P, RIA, WB
Unconjugated
500 µg/$688
PLAU / Urokinase / uPA Antibody - Formalin-fixed and paraffin-embedded human prostate carcinoma tissue reacted with PLAU antibody (C-term ), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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PLAU / Urokinase / uPA Rabbit anti-Human Polyclonal (aa396-426) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
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PLAU / Urokinase / uPA Rabbit anti-Mouse Polyclonal Antibody
Mouse, Rat
ELISA, IHC, IHC-Fr, IHC-P, WB
Unconjugated
100 µl/$371; 1 ml/$477; 10 ml/$3,251
PLAU / Urokinase / uPA Protein - Recombinant Plasminogen Activator, Urokinase By SDS-PAGE
Select
E. coli
His, N-Terminal
31.9 kDa
10 µg/$283; 50 µg/$452; 100 µg/$725; 200 µg/$905; 1 mg/$2,020; 500 µg/$1,558; 5 mg/$3,165; 2 mg/$2,209
PLAU / Urokinase / uPA ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
93.75 - 6000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
PLAU / Urokinase / uPA Antibody - IHC of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-PLAU mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).
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PLAU / Urokinase / uPA Mouse anti-Human Monoclonal (aa107-379) (OTI5H4) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
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PLAU / Urokinase / uPA Rabbit anti-Rat Polyclonal Antibody
Rat
ELISA, IHC, IHC-Fr, IHC-P, WB
Unconjugated
100 µg/$828; 1 mg/$5,539
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PLAU / Urokinase / uPA Mouse anti-Human Monoclonal (724-3A1-8) Antibody
Human
ELISA, WB
Unconjugated
1 mg/$599; 10 mg/$4,412
PLAU / Urokinase / uPA Antibody - Human Tonsil, Vessels: Formalin-Fixed, Paraffin-Embedded (FFPE)
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PLAU / Urokinase / uPA Rabbit anti-Mouse Polyclonal (aa180-433) Antibody
Mouse
IHC, IHC-P, WB
Unconjugated
50 µl/$460
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PLAU / Urokinase / uPA Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, IP, WB
Unconjugated
100 µg/$331
PLAU / Urokinase / uPA ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
PLAU / Urokinase / uPA ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.025 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Media, Plasma, Serum, Tissue Extracts, Urine
1 Plate/$896
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PLAU / Urokinase / uPA Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-Fr, IHC-P, RIA, WB
Unconjugated
500 µg/$649
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PLAU / Urokinase / uPA Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
1 mg/$990
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PLAU / Urokinase / uPA Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
1 mg/$990
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PLAU / Urokinase / uPA Mouse anti-Human Monoclonal (N-Terminus) (10D7.2) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$919
PLAU / Urokinase / uPA Antibody - Western blot of extracts of HeLa cell lines, using PLAU antibody.
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PLAU / Urokinase / uPA Rabbit anti-Human Polyclonal Antibody
Human
IHC, WB
Unconjugated
50 µl/$356; 100 µl/$461
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PLAU / Urokinase / uPA Sheep anti-Mouse Polyclonal Antibody
Mouse, Rat
ELISA, WB
Unconjugated
100 µg/$373; 1 mg/$482; 10 mg/$2,125
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PLAU / Urokinase / uPA Sheep anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$373; 1 mg/$482; 10 mg/$2,125
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PLAU / Urokinase / uPA Rabbit anti-Human Polyclonal (aa396-426) Antibody
Human
ELISA, Flo, IF, IHC, WB
Unconjugated
200 µl/$734
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PLAU / Urokinase / uPA Rabbit anti-Human Polyclonal (aa396-426) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
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PLAU / Urokinase / uPA Rabbit anti-Mouse Polyclonal Antibody
Mouse, Rat
Unconjugated
100 µg/$371; 1 mg/$477; 10 mg/$3,251
Select
PLAU / Urokinase / uPA Rabbit anti-Human Polyclonal Antibody
Human
Unconjugated
1 mg/$527; 10 mg/$3,372
PLAU / Urokinase / uPA Antibody - Western blot of recombinant PLAU / Urokinase / uPA.
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PLAU / Urokinase / uPA Rabbit anti-Mouse Polyclonal (aa180-433) (APC) Antibody
Mouse
WB
APC Conjugated
100 µl/$392; 200 µl/$470; 500 µl/$798; 1 ml/$951; 2 ml/$1,211; 5 ml/$2,269
Viewing 1-25 of 178 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).