PKN2

protein kinase N2

PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF). Phosphorylates HCV NS5B leading to stimulation of HCV RNA replication.

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Products

Antibodies (49)

Proteins (7)

Type

Over-Expression Lysate (2)

Primary (49)

Recombinant (5)

Target

PKN2 (56)

Reactivity

Human (36)

Mouse (19)

Rat (4)

Bovine (3)

Gibbon (3)

Horse (3)

Monkey (2)

Non-Human Primate (1)

Pig (3)

Rabbit (3)

Zebrafish (1)

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Application

IHC (5)

IHC-P (2)

WB (45)

Flo (4)

ELISA (5)

ICC (2)

IF (4)

IP (4)

Host

rabbit (45)

mouse (4)

Product Group

IHCPlus (1)

Isotype

IgG (9)

IgG1 (3)

IgG1,k (1)

Clonality

monoclonal mc (4)

polyclonal pc (45)

Clone

1D1 (2)

3A7 (1)

Format

APC (3)

APC Conjugated (3)

Biotin Conjugated (7)

Cy3 Conjugated (3)

Cy7 Conjugated (3)

FITC Conjugated (7)

HRP Conjugated (6)

PE Conjugated (3)

Unconjugated (17)

Epitope

aa282-487 (8)

aa323-464 (8)

aa67-312 (8)

aa605-654 (4)

aa891-940 (4)

N-Terminus (1)

aa108-141 (1)

aa200-250 (1)

aa250-300 (1)

aa46-366 (1)

Publications

No (56)

Tag

GST, N-terminus (1)

His (3)

Myc-DDK (Flag) (3)

Species

Human (5)

Mouse (1)

Source

293T Cells (1)

E. coli (3)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (1)

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PKN2 Antibody (clone 1D1) LS-C758959

Antibody:

PKN2 Mouse anti-Human Monoclonal (1D1) Antibody

Reactivity:

Mouse, Rat, Non-Human Primate, Human

Applications:

Flo, ICC, IF, IHC, WB

Format:

Unconjugated

Price:

100 µl/$541

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IHC-plus™ PKN2 Antibody (aa200-250) LS-B14078

(4.0) Rating

Antibody:

PKN2 Rabbit anti-Human Polyclonal (aa200-250) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

50 µl/$460

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PKN2 Antibody (clone 1D1) LS-C169402

Antibody:

PKN2 Mouse anti-Human Monoclonal (1D1) Antibody

Reactivity:

Mouse, Rat, Human, Monkey

Applications:

ELISA, Flo, IHC, WB

Format:

Unconjugated

Price:

100 µl/$459

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PKN2 Antibody LS-C812748

Antibody:

PKN2 Mouse anti-Human Monoclonal Antibody

Reactivity:

Mouse, Rat, Human, Monkey

Applications:

ELISA, Flo, IHC, WB

Format:

Unconjugated

Price:

50 µg/$332; 100 µg/$404; 200 µg/$505

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PKN2 Antibody LS-C752715

Antibody:

PKN2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IF, IP, WB

Format:

Unconjugated

Price:

100 µg/$331

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PKN2 Antibody LS-C670956

Antibody:

PKN2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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PKN2 Antibody (clone 3A7) LS-C197990

Antibody:

PKN2 Mouse anti-Human Monoclonal (3A7) Antibody

Reactivity:

Human

Applications:

ELISA, IF, WB

Format:

Unconjugated

Price:

100 µg/$423

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PKN2 Antibody (aa46-366) LS-C186221

Antibody:

PKN2 Rabbit anti-Human Polyclonal (aa46-366) Antibody

Reactivity:

Human

Applications:

ICC, WB

Format:

Unconjugated

Price:

100 µl/$450

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PKN2 Antibody (N-Terminus) LS-C17473

Antibody:

PKN2 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IP, WB

Format:

Unconjugated

Price:

100 µl/$688

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PKN2 Antibody (aa250-300) LS-C289179

Antibody:

PKN2 Rabbit anti-Human Polyclonal (aa250-300) Antibody

Reactivity:

Human

Applications:

IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

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PKN2 Antibody LS-C296120

Antibody:

PKN2 Rabbit anti-Mouse Polyclonal Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$306

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PKN2 Antibody (aa67-312) LS-C296121

Antibody:

PKN2 Rabbit anti-Human Polyclonal (aa67-312) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$303; 200 µl/$343; 500 µl/$476; 1 ml/$543; 2 ml/$715; 5 ml/$1,182

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PKN2 Antibody (aa67-312, HRP) LS-C710784

Antibody:

PKN2 Rabbit anti-Human Polyclonal (aa67-312) (HRP) Antibody

Reactivity:

Human

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$331; 200 µl/$383; 500 µl/$556; 1 ml/$665; 2 ml/$901; 5 ml/$1,511

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PKN2 Antibody (aa67-312, Biotin) LS-C297844

Antibody:

PKN2 Rabbit anti-Human Polyclonal (aa67-312) (Biotin) Antibody

Reactivity:

Human

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$313; 200 µl/$357; 500 µl/$503; 1 ml/$576; 2 ml/$788; 5 ml/$1,279

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PKN2 Antibody (aa67-312, FITC) LS-C693316

Antibody:

PKN2 Rabbit anti-Human Polyclonal (aa67-312) (FITC) Antibody

Reactivity:

Human

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$341; 200 µl/$397; 500 µl/$583; 1 ml/$715; 2 ml/$953; 5 ml/$1,628

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PKN2 Antibody (aa67-312, Cy3) LS-C701762

Antibody:

PKN2 Rabbit anti-Human Polyclonal (aa67-312) (Cy3) Antibody

Reactivity:

Human

Applications:

WB

Format:

Cy3 Conjugated

Price:

100 µl/$396; 200 µl/$476; 500 µl/$815; 1 ml/$969; 2 ml/$1,240; 5 ml/$2,325

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PKN2 Antibody (aa67-312, APC, Cy7) LS-C733829

Antibody:

PKN2 Rabbit anti-Human Polyclonal (aa67-312) (APC, Cy7) Antibody

Reactivity:

Human

Applications:

WB

Format:

APC, Cy7 Conjugated

Price:

100 µl/$489; 200 µl/$614; 500 µl/$1,108; 1 ml/$1,329; 2 ml/$1,860; 5 ml/$3,487

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PKN2 Antibody (aa67-312, APC) LS-C717449

Antibody:

PKN2 Rabbit anti-Human Polyclonal (aa67-312) (APC) Antibody

Reactivity:

Human

Applications:

WB

Format:

APC Conjugated

Price:

100 µl/$396; 200 µl/$476; 500 µl/$815; 1 ml/$969; 2 ml/$1,240; 5 ml/$2,325

Select

PKN2 Antibody (aa67-312, PE) LS-C724845

Antibody:

PKN2 Rabbit anti-Human Polyclonal (aa67-312) (PE) Antibody

Reactivity:

Human

Applications:

WB

Format:

PE Conjugated

Price:

100 µl/$396; 200 µl/$476; 500 µl/$815; 1 ml/$969; 2 ml/$1,240; 5 ml/$2,325

• Unconjugated
• HRP
• Biotin
• FITC
• Cy3
• APC, Cy7
• APC
• More...
  • PE

• Unconjugated
• HRP
• Biotin
• More...
  • FITC
  • Cy3
  • APC, Cy7
  • APC
  • PE

Select

PKN2 Antibody (aa891-940) LS-C170363

Antibody:

PKN2 Rabbit anti-Mouse Polyclonal (aa891-940) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

Select

PKN2 Antibody (aa282-487) LS-C296123

Antibody:

PKN2 Rabbit anti-Mouse Polyclonal (aa282-487) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$306; 200 µl/$347; 500 µl/$484; 1 ml/$553; 2 ml/$737; 5 ml/$1,206

Select

PKN2 Antibody (aa605-654) LS-C145330

Antibody:

PKN2 Rabbit anti-Human Polyclonal (aa605-654) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

Select

PKN2 Antibody (aa323-464) LS-C296122

Antibody:

PKN2 Rabbit anti-Human Polyclonal (aa323-464) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$303; 200 µl/$343; 500 µl/$476; 1 ml/$543; 2 ml/$715; 5 ml/$1,182

Select

PKN2 Antibody (FITC) LS-C302598

Antibody:

PKN2 Rabbit anti-Mouse Polyclonal (FITC) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$325

Select

PKN2 Antibody (Biotin) LS-C299835

Antibody:

PKN2 Rabbit anti-Mouse Polyclonal (Biotin) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$316

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