PKN1

protein kinase N1

PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates 'Ser-575', 'Ser-637' and 'Ser-669' of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly. Acts as a key coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-11' of histone H3 (H3T11ph), a specific tag for epigenetic transcriptional activation that promotes demethylation of histone H3 'Lys-9' (H3K9me) by KDM4C/JMJD2C. Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair their import in the nucleus. Phosphorylates 'Thr-38' of PPP1R14A, 'Ser-159', 'Ser-163' and 'Ser-170' of MARCKS, and GFAP. Able to phosphorylate RPS6 in vitro.

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Products

Antibodies (26)

Proteins (7)

ELISA Kits (6)

Type

Competitive EIA (1)

Over-Expression Lysate (2)

Primary (26)

Recombinant (5)

Sandwich (5)

Target

PKN1 (39)

Reactivity

Human (27)

Mouse (15)

Rat (13)

Bat (3)

Bovine (4)

Chimpanzee (3)

Dog (4)

Gibbon (3)

Horse (3)

Monkey (6)

Application

IHC (6)

IHC-Fr (1)

IHC-P (6)

WB (26)

Flo (2)

ELISA (6)

ICC (3)

IF (5)

IP (1)

Peptide-ELISA (2)

Host

rabbit (24)

mouse (2)

Product Group

IHCPlus (4)

Isotype

Ig (1)

IgG (7)

IgG2a,k (1)

IgG2b (1)

Clonality

monoclonal mc (2)

polyclonal pc (24)

Clone

1A4 (1)

4H10B1 (1)

Format

96-Well Strip Plate (6)

APC (1)

APC Conjugated (1)

Biotin Conjugated (2)

Cy3 Conjugated (1)

Cy7 Conjugated (1)

FITC Conjugated (2)

HRP Conjugated (2)

PE Conjugated (1)

Preservative Free (1)

Unconjugated (16)

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Epitope

aa615-874 (8)

C-Terminus (5)

Internal (1)

aa246-285 (1)

aa294-339 (1)

aa911-929 (1)

pThr778 (1)

Publications

No (39)

Sample Type

Cell Culture Supernatants (1)

Cell Lysates (2)

Plasma (4)

Serum (4)

Tissue Homogenates (2)

Tag

6His, N-terminus (1)

GST (1)

GST, N-terminus (1)

His-T7 (1)

Myc-DDK (Flag) (3)

Species

Human (6)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (2)

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IHC-plus™ PKN1 Antibody (aa246-285) LS-B13584

(4.0) Rating

Antibody:

PKN1 Rabbit anti-Human Polyclonal (aa246-285) Antibody

Reactivity:

Mouse, Bovine, Human, Monkey

Applications:

ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

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IHC-plus™ PKN1 Antibody (clone 1A4) LS-B14551

(4.0) Rating

Antibody:

PKN1 Mouse anti-Human Monoclonal (1A4) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$460

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PKN1 Antibody (clone 4H10B1) LS-C669212

Antibody:

PKN1 Mouse anti-Human Monoclonal (4H10B1) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IF, IHC, WB

Format:

Unconjugated

Price:

100 µl/$459

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PKN1 Antibody (C-Terminus) LS-C757586

Antibody:

PKN1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IF, IHC-P, WB

Format:

Unconjugated

Price:

200 µl/$393

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IHC-plus™ PKN1 Antibody LS-B14529

(4.0) Rating

Antibody:

PKN1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

Select

PKN1 Antibody (aa615-874) LS-B14604

Antibody:

PKN1 Rabbit anti-Human Polyclonal (aa615-874) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

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PKN1 Antibody (aa911-929) LS-C147990

Antibody:

PKN1 Rabbit anti-Human Polyclonal (aa911-929) Antibody

Reactivity:

Mouse, Dog, Rat, Human, Monkey

Applications:

IHC, IHC-Fr, IHC-P, IP, WB

Format:

Unconjugated

Price:

50 µl/$386

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PKN1 Antibody (Preservative Free) LS-C815405

Antibody:

PKN1 Rabbit anti-Human Polyclonal (Preservative Free) Antibody

Reactivity:

Human

Applications:

ICC, IF, WB

Format:

Unconjugated, Preservative Free

Price:

100 µl/$412

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PKN1 Antibody LS-C805656

Antibody:

PKN1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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PKN1 Antibody (aa294-339) LS-C313885

Antibody:

PKN1 Rabbit anti-Human Polyclonal (aa294-339) Antibody

Reactivity:

Mouse, Human

Applications:

ICC, WB

Format:

Unconjugated

Price:

50 µl/$321; 100 µl/$403

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PKN1 Antibody (Internal) LS-C385545

Antibody:

PKN1 Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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PKN1 Antibody LS-C781303

Antibody:

PKN1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

PKN1 Antibody LS-C824924

Antibody:

PKN1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

PKN1 Antibody LS-C802551

Antibody:

PKN1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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PKN1 Antibody (phospho-Thr778) LS-C17472

Antibody:

PKN1 Rabbit anti-Human Polyclonal (pThr778) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$689

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PKN1 Antibody (C-Terminus) LS-C201641

Antibody:

PKN1 Rabbit anti-Rat Polyclonal (C-Terminus) Antibody

Reactivity:

Rat

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

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PKN1 Antibody (C-Terminus, Biotin) LS-C459408

Antibody:

PKN1 Rabbit anti-Rat Polyclonal (C-Terminus) (Biotin) Antibody

Reactivity:

Mouse, Dog, Bovine, Rat, Horse, Bat, Gibbon, Chimpanzee, Human, Monkey

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$469

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PKN1 Antibody (C-Terminus, FITC) LS-C459409

Antibody:

PKN1 Rabbit anti-Rat Polyclonal (C-Terminus) (FITC) Antibody

Reactivity:

Mouse, Dog, Bovine, Rat, Horse, Bat, Gibbon, Chimpanzee, Human, Monkey

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• Biotin
• FITC

• Unconjugated
• Biotin
• FITC

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PKN1 Antibody (aa615-874, HRP) LS-C707484

Antibody:

PKN1 Rabbit anti-Human Polyclonal (aa615-874) (HRP) Antibody

Reactivity:

Human

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$325; 200 µl/$374; 500 µl/$537; 1 ml/$629; 2 ml/$863; 5 ml/$1,429

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PKN1 Antibody (aa615-874, Biotin) LS-C684583

Antibody:

PKN1 Rabbit anti-Human Polyclonal (aa615-874) (Biotin) Antibody

Reactivity:

Human

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$307; 200 µl/$349; 500 µl/$487; 1 ml/$556; 2 ml/$745; 5 ml/$1,209

Select

PKN1 Antibody (aa615-874, FITC) LS-C690852

Antibody:

PKN1 Rabbit anti-Human Polyclonal (aa615-874) (FITC) Antibody

Reactivity:

Human

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$334; 200 µl/$387; 500 µl/$562; 1 ml/$677; 2 ml/$914; 5 ml/$1,539

Select

PKN1 Antibody (aa615-874, APC, Cy7) LS-C730551

Antibody:

PKN1 Rabbit anti-Human Polyclonal (aa615-874) (APC, Cy7) Antibody

Reactivity:

Human

Applications:

WB

Format:

APC, Cy7 Conjugated

Price:

100 µl/$475; 200 µl/$587; 500 µl/$1,064; 1 ml/$1,257; 2 ml/$1,759; 5 ml/$3,297

Select

PKN1 Antibody (aa615-874, APC) LS-C715664

Antibody:

PKN1 Rabbit anti-Human Polyclonal (aa615-874) (APC) Antibody

Reactivity:

Human

Applications:

WB

Format:

APC Conjugated

Price:

100 µl/$387; 200 µl/$462; 500 µl/$774; 1 ml/$929; 2 ml/$1,189; 5 ml/$2,199

Select

PKN1 Antibody (aa615-874, Cy3) LS-C698465

Antibody:

PKN1 Rabbit anti-Human Polyclonal (aa615-874) (Cy3) Antibody

Reactivity:

Human

Applications:

WB

Format:

Cy3 Conjugated

Price:

100 µl/$387; 200 µl/$462; 500 µl/$774; 1 ml/$929; 2 ml/$1,189; 5 ml/$2,199

Select

PKN1 Antibody (aa615-874, PE) LS-C721548

Antibody:

PKN1 Rabbit anti-Human Polyclonal (aa615-874) (PE) Antibody

Reactivity:

Human

Applications:

WB

Format:

PE Conjugated

Price:

100 µl/$387; 200 µl/$462; 500 µl/$774; 1 ml/$929; 2 ml/$1,189; 5 ml/$2,199

• HRP
• Biotin
• FITC
• APC, Cy7
• APC
• Cy3
• PE

• HRP
• Biotin
• FITC
• More...
  • APC, Cy7
  • APC
  • Cy3
  • PE

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