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PKM / Pyruvate Kinase, Muscle
pyruvate kinase, muscle
This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported.
| Gene Name: | pyruvate kinase, muscle |
| Synonyms: | PKM, p58, PK3, PKM2, Pyruvate Kinase, Pyruvate kinase 2/3, Pyruvate kinase, m1, Pyruvate kinase, muscle, TCB, Tumor M2-PK, OIP-3, OIP3, Opa-interacting protein 3, CTHBP, PK, muscle type, PK2, Pyruvate kinase isozymes M1/M2, Pyruvate kinase muscle isozyme, THBP1 |
| Target Sequences: | NM_002654 NP_002645.3 P14618 |
Publications (2)
1
Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1. Luo W, Hu H, Chang R, Zhong J, Knabel M, O'Meally R, Cole RN, Pandey A, Semenza GL. Cell. 2011 145:732-44. (WB, ChrIP; Human)
[PubMed:21620138]
[PMC:PMC3130564]
2
Enhancing mitochondrial respiration suppresses tumor promoter TPA-induced PKM2 expression and cell transformation in skin epidermal JB6 cells. Wittwer JA, Robbins D, Wang F, Codarin S, Shen X, Kevil CG, Huang TT, Van Remmen H, Richardson A, Zhao Y. Cancer prevention research (Philadelphia, Pa.). 2011 4:1476-84.
[PubMed:21673231]
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PKM / Pyruvate Kinase, Muscle Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human, Monkey
IHC, IHC-Fr, IHC-P, WB
Unconjugated
50 µl/$565
PKM / Pyruvate Kinase, Muscle Goat anti-Rabbit Polyclonal Antibody
Rabbit, Human
ELISA, IHC, IHC-P, IP, WB
Unconjugated
50 µl/$440
PKM / Pyruvate Kinase, Muscle Rabbit anti-Human Polyclonal (aa476-505) Antibody
Mouse, Rat, Primate, Human
IF, IHC, IHC-P, WB
Unconjugated
200 µl/$393
PKM / Pyruvate Kinase, Muscle Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA, IHC, IHC-P, WB
HRP Conjugated
50 µg/$294; 100 µg/$360
PKM / Pyruvate Kinase, Muscle Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, IHC, IHC-P, WB
Biotin Conjugated
50 µg/$294; 100 µg/$360
PKM / Pyruvate Kinase, Muscle Rabbit anti-Human Polyclonal Antibody
Human
IF, IHC, IHC-P, IP, RnaIP, WB
Unconjugated
50 µl/$460
Sandwich
96-Well Strip Plate
Human
78.125 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$768
PKM / Pyruvate Kinase, Muscle Rabbit anti-Human Polyclonal (aa121-151) Antibody
Mouse, Human
WB
Unconjugated
400 µl/$393
PKM / Pyruvate Kinase, Muscle Rabbit anti-Human Polyclonal (aa116-145) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
Sandwich
96-Well Strip Plate
Mouse
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$782
PKM / Pyruvate Kinase, Muscle Rabbit anti-Human Polyclonal (aa481-531) Antibody
Mouse, Human
IHC, IP, WB
Unconjugated
20 µl/$295; 100 µl/$414
PKM / Pyruvate Kinase, Muscle Rabbit anti-Human Polyclonal (aa181-230) Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
PKM / Pyruvate Kinase, Muscle Rabbit anti-Human Polyclonal (pTyr105) Antibody
Mouse, Human
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
PKM / Pyruvate Kinase, Muscle Rabbit anti-Human Polyclonal (aa350-450) Antibody
Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
0.1 ml/$386
PKM / Pyruvate Kinase, Muscle Rabbit anti-Human Polyclonal (aa350-450) (Biotin) Antibody
Mouse, Rat, Human
ICC, IF, IHC, IHC-P, WB
Biotin Conjugated
0.1 ml/$416
PKM / Pyruvate Kinase, Muscle Rabbit anti-Human Polyclonal (aa350-450) (DY488) Antibody
Human
ICC, IF, IHC, IHC-P, WB
DY488 Conjugated
0.1 ml/$416
PKM / Pyruvate Kinase, Muscle Rabbit anti-Human Polyclonal (aa350-450) (DY650) Antibody
Human
ICC, IF, IHC, IHC-P, WB
DY650 Conjugated
0.1 ml/$416
PKM / Pyruvate Kinase, Muscle Rabbit anti-Human Polyclonal (aa350-450) (DY550) Antibody
Human
ICC, IF, IHC, IHC-P, WB
DY550 Conjugated
0.1 ml/$416
PKM / Pyruvate Kinase, Muscle Rabbit anti-Human Polyclonal (aa383-417) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
200 µl/$460
PKM / Pyruvate Kinase, Muscle Rabbit anti-Human Polyclonal (aa391-440) Antibody
Human
WB
Unconjugated
100 µl/$424
PKM / Pyruvate Kinase, Muscle Rabbit anti-Human Polyclonal (aa77-91) Antibody
Xenopus, Bat, Rat, Pig, Horse, Rabbit, Mouse, Guinea pig, Sheep, Bovine, Human, Monkey
WB
Unconjugated
10 µg/$318; 100 µg/$470
PKM / Pyruvate Kinase, Muscle Rabbit anti-Human Polyclonal (aa476-505) Antibody
Mouse, Rat, Primate, Human
ELISA, IF, IHC, WB
Unconjugated
200 µl/$734
PKM / Pyruvate Kinase, Muscle Rabbit anti-Human Polyclonal (aa476-505) (FITC) Antibody
Mouse, Rat, Primate, Human
ELISA, ICC, IF, IHC, WB
FITC Conjugated
200 µl/$952
PKM / Pyruvate Kinase, Muscle Rabbit anti-Human Polyclonal (aa476-505) (PE) Antibody
Mouse, Rat, Primate, Human
ELISA, ICC, IF, IHC, WB
PE Conjugated
200 µl/$952
PKM / Pyruvate Kinase, Muscle Rabbit anti-Human Polyclonal (aa476-505) (APC) Antibody
Mouse, Rat, Primate, Human
ELISA, ICC, IF, IHC, WB
APC Conjugated
200 µl/$952
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product results
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