Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
PKLR Antibody, PKL Antibody, Pyruvate kinase, liver and RBC Antibody, Pyruvate kinase type L Antibody, Red cell/liver pyruvate kinase Antibody, RPK Antibody, PK1 Antibody, PKR Antibody, Pyruvate kinase 1 Antibody, Pyruvate kinase isozymes R/L Antibody, R-type/L-type pyruvate kinase Antibody, PKRL Antibody, Pyruvate kinase isozyme R/L Antibody
PKLR is a pyruvate kinase that catalyzes the transphosphorylation of phohsphoenolpyruvate into pyruvate and ATP, which is the rate-limiting step of glycolysis. Defects in this enzyme, due to gene mutations or genetic variations, are the common cause of chronic hereditary nonspherocytic hemolytic anemia (CNSHA or HNSHA). Multiple transcript variants encoding different isoforms have been found for this gene.
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
The anti-PKLR antibody is used in Western blot to detect PKLR in NIH/3T3 cell lysate.
PKLR Antibody (S8) western blot of NCI-H292 cell line lysates (35 ug/lane). The PKLR antibody detected the PKLR protein (arrow).